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Antibacterial effect of the red sea soft coral Sarcophyton trocheliophorum
King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia..
King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia..
King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
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2016 (English)In: Natural Product Research, ISSN 1478-6419, E-ISSN 1478-6427, Vol. 30, no 6, 729-734 p.Article in journal (Refereed) Published
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Abstract [en]

The marine soft corals Sarcophyton trocheliophorum crude extracts possessed antimicrobial activity towards pathogenic bacterial strains, i.e. Bacillus cereus, Salmonella typhi, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Bioassay-guided fractionation indicated that the antimicrobial effect was due to the presence of terpenoid bioactive derivatives. Further biological assays of the n-hexane fractions were carried out using turbidity assay, inhibition zone assay and minimum inhibitory concentration for investigating the growth-inhibition effect towards the Gram-positive and Gram-negative bacteria. The fractions were screened and the structure of the isolated compound was justified by interpretation of the spectroscopic data, mainly mass spectrometry (GC-MS). The structure was assigned as (5S)-3-[(3E,5S)-5-hydroxy-3-hepten-6-yn-1-yl]-5-methyl-2(5H)-furanone and was effective at concentrations as low as 0.20mg/mL. The above findings, in the course of our ongoing research on marine products, may implicate that the profound anti-microbial activity of the S. trocheliophorum soft corals, inhabiting the red sea reefs, is attributed to the presence of growth-inhibiting secondary metabolites mainly terpenoids.

Place, publisher, year, edition, pages
2016. Vol. 30, no 6, 729-734 p.
Keyword [en]
soft coral, Sarcophyton trocheliophorum, terpenoid, in vitro, antimicrobial assays
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-277769DOI: 10.1080/14786419.2015.1040991ISI: 000368583100017PubMedID: 26186031OAI: oai:DiVA.org:uu-277769DiVA: diva2:905869
Available from: 2016-02-23 Created: 2016-02-23 Last updated: 2017-11-30Bibliographically approved

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