uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate.
Show others and affiliations
2013 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 433, no 4Article in journal (Refereed) Published
Abstract [en]

Bile acids have emerged as a new class of signaling molecules that play a role in metabolism. Studies in mice have shown that the bile acid receptor TGR5 mediates several of these effects but the metabolic function of TGR5 in humans is less well established. Here we show that human adipose tissue TGR5 expression is positively correlated to obesity and reduced during diet-induced weight loss. Adipose tissue TGR5 expression was also positively correlated to resting metabolic rate. Our study indicates that human adipose tissue contributes to the TGR5 mediated metabolic effects of bile acids and plays a role in energy expenditure.

Place, publisher, year, edition, pages
2013. Vol. 433, no 4
National Category
Cell and Molecular Biology
URN: urn:nbn:se:uu:diva-278137DOI: 10.1016/j.bbrc.2013.03.031PubMedID: 23523790OAI: oai:DiVA.org:uu-278137DiVA: diva2:906154
Available from: 2016-02-23 Created: 2016-02-23 Last updated: 2016-02-23

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Pereira, Maria J
By organisation
Department of Medical Sciences
In the same journal
Biochemical and Biophysical Research Communications - BBRC
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 29 hits
ReferencesLink to record
Permanent link

Direct link