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Arabidopsis COP1 SUPPRESSOR 2 Represses COP1 E3 Ubiquitin Ligase Activity through Their Coiled-Coil Domains Association
Peking Univ, Peking Tsinghua Ctr Life Sci, Sch Adv Agr Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China.;Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China.;Gothenburg Univ, Dept Biol & Environm Sci, Gothenburg, Sweden..
Peking Univ, Peking Tsinghua Ctr Life Sci, Sch Adv Agr Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China.;Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China..
Peking Univ, Peking Tsinghua Ctr Life Sci, Sch Adv Agr Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China.;Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China.;Gothenburg Univ, Dept Biol & Environm Sci, Gothenburg, Sweden..
Peking Univ, Peking Tsinghua Ctr Life Sci, Sch Adv Agr Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China.;Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China..
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2015 (English)In: PLoS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 11, no 12, e1005747Article in journal (Refereed) Published
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Abstract [en]

CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) functions as an E3 ubiquitin ligase and mediates a variety of developmental processes in Arabidopsis by targeting a number of key regulators for ubiquitination and degradation. Here, we identify a novel COP1 interacting protein, COP1 SUPPRESSOR 2 (CSU2). Loss of function mutations in CSU2 suppress the constitutive photomorphogenic phenotype of cop1-6 in darkness. CSU2 directly interacts with COP1 via their coiled-coil domains and is recruited by COP1 into nuclear speckles in living plant cells. Furthermore, CSU2 inhibits COP1 E3 ubiquitin ligase activity in vitro, and represses COP1 mediated turnover of HY5 in cell-free extracts. We propose that in csu2 cop1-6 mutants, the lack of CSU2's repression of COP1 allows the low level of COP1 to exhibit higher activity that is sufficient to prevent accumulation of HY5 in the dark, thus restoring the etiolated phenotype. In addition, CSU2 is required for primary root development under normal light growth condition.

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2015. Vol. 11, no 12, e1005747
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Genetics
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URN: urn:nbn:se:uu:diva-277894DOI: 10.1371/journal.pgen.1005747ISI: 000368518400070PubMedID: 26714275OAI: oai:DiVA.org:uu-277894DiVA: diva2:906992
Available from: 2016-02-25 Created: 2016-02-23 Last updated: 2017-11-30Bibliographically approved

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Tellgren-Roth, Christian

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