Optimizing testing methods and collection of reference data for differentiating critical illness polyneuropathy from critical illness myopathy.
2016 (English)In: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 53, no 4, 555-563 p.Article in journal (Refereed) Published
INTRODUCTION: In severe acute quadriplegic myopathy in intensive care unit (ICU) patients, muscle fibers are electrically inexcitable; in critical illness polyneuropathy the excitability remains normal. Conventional electrodiagnostic methods do not provide the means to adequately differentiate between them.
OBJECTIVE: To further optimize methodology for the study of critically ill ICU patients and to create a reference database in healthy controls.
METHODS: Different electrophysiologic protocols were tested to find sufficiently robust and reproducible techniques for clinical diagnostic applications.
RESULTS: Many parameters show large test-retest variability within the same healthy subject. Reference values have been collected and described as a basis for studies of weakness in critical illness.
DISCUSSION: Using the ratio of neCMAP/dmCMAP (response from nerve and direct muscle stimulation), refractory period, and stimulus-response curves may optimize the electrodiagnostic differentiation of patients with critical illness myopathy from those with critical illness polyneuropathy.
Place, publisher, year, edition, pages
2016. Vol. 53, no 4, 555-563 p.
Other Clinical Medicine
IdentifiersURN: urn:nbn:se:uu:diva-267714DOI: 10.1002/mus.24886ISI: 000373348300010PubMedID: 26311145OAI: oai:DiVA.org:uu-267714DiVA: diva2:907149