uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cyclotides in the Violaceae
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy. (Ulf Goransson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. (Ulf Goransson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy. W.SZAFER INSTITUTE OF BOTANY OF THE POLISH ACADEMY OF SCIENCES. (Ulf Goransson)
2015 (English)In: Plant Cyclotides / [ed] Craik, David J., Academic Press , 2015, Vol. 76, 15-49 p.Chapter in book (Other academic)
Resource type
Text
Abstract [en]

Abstract It has been 20 years since the cyclic cystine-knotted compounds, called cyclotides, tied our knot with the violets. This chapter, above all, is a lucid summary of the twists, turns, knots, and rings in the relationship that followed. The chapter begins by giving an account of how a little known scientific article facilitated the discovery of cyclotides in Violaceae, how it captured our imagination, and how it was realized that the discovery of a series of cyclotides was within a touching distance. The processes of extraction, isolation, and characterization as well as chemical synthesis of cyclotides used in our laboratory have been described, and in doing so, the solvents, materials, conditions, instrumentation, and techniques involved have been pointed out. An introduction to Violaceae and a description of these plants in diverse cultural settings for various therapeutic purposes is provided. A section follows it on the discovery of cycloviolacin O2 from Viola odorata as a potent antimicrobial peptide, and how its interaction with bacteria in terms of mechanism of action and resistance development was investigated. It is followed by a reflection on how the recent innovations in biotechnology and bioinformatics have helped out along the way: the use of novel strategies for cyclization and the use of transcriptomics data in the discovery of new cyclotides. Finally, the question about biological role of cyclotides in Violaceae has been asked, and an attempt to answer this question has been presented.

Place, publisher, year, edition, pages
Academic Press , 2015. Vol. 76, 15-49 p.
Series
Advances in Botanical Research, 76
Keyword [en]
Cyclotides, Discovery, Pharmacognosy, Traditional medicine, Violaceae
National Category
Botany
Research subject
Pharmacognosy
Identifiers
URN: urn:nbn:se:uu:diva-278985DOI: 10.1016/bs.abr.2015.09.001ISI: 000376190900003ISBN: 9780128007976 (print)ISBN: 9780128000304 (print)OAI: oai:DiVA.org:uu-278985DiVA: diva2:907329
Available from: 2016-02-27 Created: 2016-02-27 Last updated: 2016-07-19Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Göransson, UlfMalik, SohaibSlazak, Blazej

Search in DiVA

By author/editor
Göransson, UlfMalik, SohaibSlazak, Blazej
By organisation
Division of PharmacognosyDepartment of Medical Biochemistry and Microbiology
Botany

Search outside of DiVA

GoogleGoogle Scholar

doi
isbn
urn-nbn

Altmetric score

doi
isbn
urn-nbn
Total: 727 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf