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Gabapentin för smärtbehandling vid elektiv knäplastik på Södersjukhuset
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2015 (Swedish)Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesisAlternative title
Gabapentin in pain management for patients undergoing elective arthroplastic operations at Södersjukhuset (English)
Abstract [en]



Gabapentin in pain management for patients undergoing elective arthroplastic operations at Södersjukhuset


Ibrahim Bengtsson L


Uppsala University, Uppsala, Sweden

Background and Objective

Postoperative pain after total knee arthroplasty TKA, often delays rehabilitation and discharge from hospital. The use of analgesics like opioids can cause adverse effects such as dizziness, itching, nausea and vomiting. This study was conducted to retrospectively examine perioperative gabapentin regimen versus opioid regimen regarding efficacy and adverse effects in a population of adults who underwent elective TKA at Södersjukhuset in Stockholm.

Design and setting

Retrospective chart review of medical records within the inpatient care at Södersjukhuset in Stockholm, conducted in April 2015. A perioperative gabapentin regimen in a fixed dose was compared to a perioperative oxikodon depot regimen.

Main outcome measures

The primary outcomes were to compare pain cores, knee flexion, hospital stay and adverse effects. The secondary outcome was to examine if gabapentin could minimize opioid consumption compared to the other group during hospital stay after TKA.


Data on 88 patients was evaluated, 44 patients from gabapentin, (group A) and 44 patients from opioid group (Group B).  Patients from group A needed significantly less opioid at 24 h, 72 h and the time >72 h (P< 0,05). Group A had significantly better active knee flexion on postoperative days 2 and 3. There were no differences in pain scores, hospital stay and adverse effects such as confusion, nausea and vomiting.


The results support the use of gabapentin in postoperative pain management but further trials are needed to determine the optimal dose and to find better alternatives than opioids to combine with gabapentin.

Place, publisher, year, edition, pages
2015. , 10 p.
Keyword [en]
gabapentin and arthroplastic operations, gabapentin and TKA, gabapentin i acute paim managment, perioperative gabapentin versus opioid
Keyword [sv]
gabapentin vid akut smärta, gabapentin mot opioider, knäplatik, gabapentin and TKA, opioidsparande vid ortopediska operationer
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-279020OAI: oai:DiVA.org:uu-279020DiVA: diva2:907393
External cooperation
Subject / course
Pharmaceutical Biosciences
Educational program
Master Programme in Clinical Pharmacy
Available from: 2016-02-29 Created: 2016-02-27 Last updated: 2016-02-29Bibliographically approved

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