Folate and B12 serum levels in association with depression in the aged: a systematic review and meta-analysis
2016 (English)In: Aging & Mental Health, ISSN 1360-7863, E-ISSN 1364-6915, Vol. 20, no 9, 965-973 p.Article in journal (Refereed) Published
OBJECTIVES: To systematically review and meta-analyse existing evidence on the association between folate/B12, and depression among the aged people.
METHODS: Following PRISMA/STROBE guidelines, the Medline abstracts were retrieved using an algorithm comprising relevant MeSH terms. Publications on the association of folate/B12 serum measurements with depression were abstracted independently by two reviewers and included in both gender and gender-specific meta-analyses, following recarculations of published data as appropriate. The Newcastle-Ottawa scale was used to evaluate the quality of included studies.
RESULTS: Both gender data were contributed by 11 folate-related (7949 individuals) and 9 B12-related studies (6308 individuals), whereas gender-specific data by 4 folate-related (3409 individuals) and 3 B12-related studies (1934 individuals). A statistically significant overall association between both exposures of interest (low folate and B12 levels) and depression was observed (ORfolate:1.23, 95%CI:1.07-1.43, ORB12:1.20, 95%CI:1.02-1.42). Gender-specific estimates pointed to a statistically significant positive association between low B12 levels and depression only among women (OR:1.33, 95%CI:1.02-1.74); the gender specific associations of low folate levels with depression were, however, non-significant and of counter-direction (ORfemales:1.37, 95%CI:0.90-2.07; ORmales:0.84, 95%CI:0.57-1.25).
CONCLUSION: Low folate and B12 serum levels seem to be associated with depression in the aged. The gender-specific analyses are confined to a positive association of low B12 with depression among older women and call for further research in this direction.
Place, publisher, year, edition, pages
2016. Vol. 20, no 9, 965-973 p.
folate; vitamin B12; depression; meta-analysis; gender; geriatric
IdentifiersURN: urn:nbn:se:uu:diva-279110DOI: 10.1080/13607863.2015.1049115ISI: 000381401500009PubMedID: 26055921OAI: oai:DiVA.org:uu-279110DiVA: diva2:907575