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Models for Predicting Drug Absorption From Oral Lipid-Based Formulations
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2015 (English)In: Current molecular biology reports, ISSN 2198-6428, Vol. 1, no 4, 141-147 p.Article in journal (Refereed) Published
Abstract [en]

In this review, we describe the in vitro tools currently used to identify when a lipid-based formulation has the potential to deliver a poorly water-soluble drug via the oral route. We describe the extent to which these tools reflect the in vivo performance of the formulation and, more importantly, we present strategies that we foresee will improve the in vitro-in vivo correlations. We also present emerging computational methods that are likely to allow large parts of the formulation development to be carried out in the computer rather than in the test tube. We suggest that these computational tools will also improve the mechanistic understanding of in vivo formulation performance in the complex and dynamic environment of the gut.

Place, publisher, year, edition, pages
2015. Vol. 1, no 4, 141-147 p.
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-279179DOI: 10.1007/s40610-015-0023-1PubMedID: 26594613OAI: oai:DiVA.org:uu-279179DiVA: diva2:907655
Available from: 2016-02-29 Created: 2016-02-29 Last updated: 2017-04-13Bibliographically approved

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Alskär, Linda CBergström, Christel A S

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