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Tumor-Induced Local and Systemic Impact on Blood Vessel Function
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2015 (English)In: Mediators of Inflammation, ISSN 0962-9351, E-ISSN 1466-1861, 418290Article, review/survey (Refereed) Published
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Abstract [en]

Endothelial dysfunction plays a role in several processes that contribute to cancer-associated mortality. The vessel wall serves as a barrier for metastatic tumor cells, and the integrity and activation status of the endothelium serves as an important defense mechanism against metastasis. In addition, leukocytes, such as cytotoxic T-cells, have to travel across the vessel wall to enter the tumor tissue where they contribute to killing of cancer cells. Tumor cells can alter the characteristics of the endothelium by recruitment of leukocytes such as neutrophils andmacrophages, which further stimulate inflammation and promote tumorigenesis. Recent findings also suggest that leukocyte-mediated effects on vascular function are not limited to the primary tumor or tissues that represent metastatic sites. Peripheral organs, such as kidney and heart, also display impaired vascular function in tumor-bearing individuals, potentially contributing to organ failure. Here, we discuss how vascular function is altered in malignant tissue and distant organs in individuals with cancer and how leukocytes function as potent mediators of these tumor-induced effects.

Place, publisher, year, edition, pages
2015. 418290
National Category
Cancer and Oncology Medical Genetics
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URN: urn:nbn:se:uu:diva-279222DOI: 10.1155/2015/418290ISI: 000366855100001OAI: oai:DiVA.org:uu-279222DiVA: diva2:908151
Available from: 2016-03-01 Created: 2016-02-29 Last updated: 2017-11-30Bibliographically approved

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Cedervall, JessicaDimberg, AnnaOlsson, Anna-Karin

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