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Expression of cellular retinol- and retinoic acid-binding proteins in normal and pathologic human parathyroid glands
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Osteoporos, S Ljunghall)
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2001 (English)In: Endocrine pathology, ISSN 1046-3976, Vol. 12, no 4, 423-427 p.Article in journal (Refereed) Published
Abstract [en]

We have previously reported data establishing the human parathyroid gland as a target organ for vitamin A. In the present study, we identified Ito-like cells in parathyroid glands, suggesting local stores of vitamin A. Furthermore, we used immunohistochemistry to investigate the expression of the cellular retinol-binding protein type 1 and the cellular retinoic acid-binding protein type 1 (CRABP I) in histologically normal glands, in remnants of "normal" glandular tissue adjacent to adenoma, in adenomas, and in hyperplastic glands of chief cell type. All normal and abnormal glands displayed immunoreactivity to the two antibodies. CRABP I appeared in the cytoplasm, cell membranes, and nuclear membranes in normal glands, but only exceptionally in the nuclear membranes in abnormal glands. Since retinoic acid inhibits the secretion of parathyroid hormone and CRABP I is thought to play a key role in regulating the amount of retinoic acid available to interact with specific nuclear receptors, these data may suggest impaired transport of retinoic acid to cell nuclei, thus contributing to the development of hyperparathyroidism.

Place, publisher, year, edition, pages
2001. Vol. 12, no 4, 423-427 p.
Keyword [en]
Vitamin A, parathyroid, retinoic acid, immunohistochemistry, CRBP, CRABP
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-62919DOI: 10.1385/EP:12:4:423PubMedID: 11914476OAI: oai:DiVA.org:uu-62919DiVA: diva2:90830
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2009-11-13Bibliographically approved

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