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Definition of nocturnal gastroesophageal reflux for studies on respiratory diseases
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research. Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Resp Med & Sleep, Reykjavik, Iceland..
Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Resp Med & Sleep, Reykjavik, Iceland..
Landspitali Univ Hosp, Dept Clin Biochem, Reykjavik, Iceland..
Landspitali Univ Hosp, Dept Clin Biochem, Reykjavik, Iceland..
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2016 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 51, no 5, p. 524-530Article in journal (Refereed) Published
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Abstract [en]

Objective Nocturnal gastroesophageal reflux (nGER) has been associated with respiratory diseases. Our aim was to study a questionnaire method to identify nGER subjects with respiratory involvement in a general population. Material and methods A subgroup of Icelandic participants in the European Community Respiratory Health Survey III (ECRHS III) reporting symptoms of nGER (n =48) as well as age and gender paired controls (n =42) were studied further by a structured interview, questionnaires, laryngeal fibrescopy, and exhaled breath condensate. A subgroup underwent 24-h oesophageal pH impedance (24-h MII-pH) measurements. Symptoms of nGER were assessed with a modified version of the reflux disease questionnaire (RDQ), where symptoms were divided into daytime and nocturnal. A report of nGER both at baseline and at follow-up was defined as persistent nGER. Results Participants reporting persistent nGER had significantly more signs of laryngopharyngeal reflux according to the reflux finding score than those without nGER (Mean +/- SD: 5.1 +/- 2.3 vs. 3.9 +/- 2.2, p =0.02). Of the 16 persistent nGER subjects that underwent 24-h MII-pH, 11 had abnormal gastroesophageal reflux, but none of three control subjects (69% vs. 0%). Pepsin was more commonly found in exhaled breath condensate in the nGER group (67% vs. 45%, p =0.04). Conclusions Participants with nGER symptoms at least once a month, reported on two occasions, had a high level of positive 24-h MII-pH measurements, laryngeal inflammation and pepsin in exhaled breath condensate. This nGER definition identified a representable group for studies on nGER and respiratory diseases in a general population.

Place, publisher, year, edition, pages
2016. Vol. 51, no 5, p. 524-530
Keyword [en]
Asthma, laryngopharyngeal reflux, nocturnal gastroesophageal reflux, pepsin, reflux disease questionnaire
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:uu:diva-279545DOI: 10.3109/00365521.2015.1124284ISI: 000369846300002PubMedID: 26825677OAI: oai:DiVA.org:uu-279545DiVA, id: diva2:908498
Available from: 2016-03-02 Created: 2016-03-02 Last updated: 2018-02-19Bibliographically approved

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Emilsson, Össur IngiNordang, LeifJanson, Christer

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