Multifunctional Antioxidants: Regenerable Radical-Trapping and Hydroperoxide-Decomposing Ebselenols
2016 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 55, no 11, 3729-3733 p.Article in journal (Refereed) Published
Regenerable, multifunctional ebselenol antioxidants were prepared that could quench peroxyl radicals more efficiently than -tocopherol. These compounds act as better mimics of the glutathione peroxidase enzymes than ebselen. Production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in human mononuclear cells was considerably decreased upon exposure to the organoselenium compounds. At a concentration of 25m, the ebselenol derivatives showed minimal toxicity in pre-osteoblast MC3T3cells.
Place, publisher, year, edition, pages
2016. Vol. 55, no 11, 3729-3733 p.
Natural Sciences Engineering and Technology
IdentifiersURN: urn:nbn:se:uu:diva-280006DOI: 10.1002/anie.201510947ISI: 000371521000034PubMedID: 26879742OAI: oai:DiVA.org:uu-280006DiVA: diva2:909435
FunderSwedish Research CouncilCarl Tryggers foundation , 13:346, 13:120