uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Prognosis of long-term survival considering disease-specific death in patients with chronic myeloid leukemia
Univ Munich, Inst Med Informationsverarbeitung Biometrie & Epi, Marchioninistr 15, D-81377 Munich, Germany..
Univ Bologna, S Orsola Malpighi Hosp, Hematol & Oncol L&A Seragnoli, Bologna, Italy..
Heidelberg Univ, Med Fak Mannheim, Univ Med Mannheim, Med Klin 3, Mannheim, Germany..
CHU Poitiers, INSERM, CIC 1402, Clin Invest Ctr, Poitiers, France..
Show others and affiliations
2016 (English)In: Leukemia, ISSN 0887-6924, E-ISSN 1476-5551, Vol. 30, no 1, 48-56 p.Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

In patients with chronic myeloid leukemia (CML), first-line imatinib treatment leads to 8-year overall survival (OS) probabilities above 80%. Many patients die of reasons unrelated to CML. This work tackled the reassessment of prognosis under particular consideration of the probabilities of dying of CML. Analyses were based on 2290 patients with chronic phase CML treated with imatinib in six clinical trials. 'Death due to CML' was defined by death after disease progression. At 8 years, OS was 89%. Of 208 deceased patients, 44% died of CML. Higher age, more peripheral blasts, bigger spleen and low platelet counts were significantly associated with increased probabilities of dying of CML and determined a new long-term survival score with three prognostic groups. Compared with the low-risk group, the patients of the intermediate-and the high-risk group had significantly higher probabilities of dying of CML. The score was successfully validated in an independent sample of 1120 patients. In both samples, the new score differentiated probabilities of dying of CML better than the Sokal, Euro and the European Treatment and Outcome Study (EUTOS) score. The new score identified 61% low-risk patients with excellent long-term outcome and 12% high-risk patients. The new score supports the prospective assessment of long-term antileukemic efficacy and risk-adapted treatment.

Place, publisher, year, edition, pages
2016. Vol. 30, no 1, 48-56 p.
National Category
Cancer and Oncology Hematology
Identifiers
URN: urn:nbn:se:uu:diva-279640DOI: 10.1038/leu.2015.261ISI: 000369481600006PubMedID: 26416462OAI: oai:DiVA.org:uu-279640DiVA: diva2:909997
Available from: 2016-03-08 Created: 2016-03-02 Last updated: 2017-11-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Simonsson, Bengt

Search in DiVA

By author/editor
Simonsson, Bengt
By organisation
Haematology
In the same journal
Leukemia
Cancer and OncologyHematology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 212 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf