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Cohort Effects in the Prevalence and Survival of People with Dementia in a Rural Area in Northern Sweden
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Karolinska Inst, ARC, Stockholm, Sweden.;Stockholm Univ, S-10691 Stockholm, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Stockholm, Sweden..
Karolinska Inst, ARC, Stockholm, Sweden.;Stockholm Univ, S-10691 Stockholm, Sweden.;Univ Gavle, Gavle, Sweden..
Karolinska Inst, ARC, Stockholm, Sweden.;Stockholm Univ, S-10691 Stockholm, Sweden..
Karolinska Inst, ARC, Stockholm, Sweden.;Stockholm Univ, S-10691 Stockholm, Sweden..
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2016 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 50, no 2, 387-396 p.Article in journal (Refereed) Published
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Abstract [en]

Background: Recent studies suggest that trends in cardiovascular risk may result in a decrease in age-specific prevalence of dementia. Studies in rural areas are rare. Objectives: To study cohort effects in dementia prevalence and survival of people with dementia in a Swedish rural area. Methods: Participants were from the 1995-1998 Nordanstig Project (NP) (n = 303) and the 2001-2003 Swedish National study on Aging and Care in Nordanstig (SNAC-N) (n = 384). Overall 6-year dementia prevalence and mortality in NP and SNAC-N were compared for people 78 years and older. Logistic regression analyses were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for dementia occurrence using the NP study population as the reference group. Cox regression models were used to analyze time to death. Results: The crude prevalence of dementia was 21.8% in NP and 17.4% in SNAC-N. When the NP cohort was used as the reference group, the age- and gender-adjusted OR of dementia was 0.71 (95% CI 0.48-1.04) in SNAC-N; the OR was 0.47 (0.24-0.90) for men and 0.88 (0.54-1.44) for women. In the extended model, the OR of dementia was significantly lower in SNAC-N than in the NP cohort as a whole (0.63; 0.39-0.99) and in men (0.34; 0.15-0.79), but not in women (0.81; 0.46-1.44). The Cox regression models indicated that the hazard ratio of dying was lower in the SNAC-N than NP population. Conclusions: Trends toward a lower prevalence of dementia in high-income countries seem to be evident in this Swedish rural area, at least in men.

Place, publisher, year, edition, pages
2016. Vol. 50, no 2, 387-396 p.
Keyword [en]
Dementia, mortality, prevalence, rural population
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-280101DOI: 10.3233/JAD-150708ISI: 000368929200006PubMedID: 26639970OAI: oai:DiVA.org:uu-280101DiVA: diva2:910117
Funder
Public Health Agency of Sweden Stockholm County CouncilForte, Swedish Research Council for Health, Working Life and Welfare
Available from: 2016-03-08 Created: 2016-03-08 Last updated: 2017-11-30Bibliographically approved

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