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GC-biased gene conversion links the recombination landscape and demography to genomic base composition: GC-biased gene conversion drives genomic base composition across a wide range of species
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
2015 (English)In: Bioessays, ISSN 0265-9247, E-ISSN 1521-1878, Vol. 37, no 12, 1317-1326 p.Article in journal (Refereed) Published
Abstract [en]

The origin and evolutionary dynamics of the spatial heterogeneity in genomic base composition have been debated since its discovery in the 1970s. With the recent availability of numerous genome sequences from a wide range of species it has been possible to address this question from a comparative perspective, and similarities and differences in base composition between groups of organisms are becoming evident. Ample evidence suggests that the contrasting dynamics of base composition are driven by GC-biased gene conversion (gBGC), a process that is associated with meiotic recombination. In line with this hypothesis, base composition is associated with the rate of recombination and the evolutionary dynamics of the recombination landscape, therefore, governs base composition. In addition, and at first sight perhaps surprisingly, the relationship between demography and genomic base composition is in agreement with the gBGC hypothesis: organisms with larger populations have higher GC content than those with smaller populations.

Place, publisher, year, edition, pages
2015. Vol. 37, no 12, 1317-1326 p.
National Category
Evolutionary Biology Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-280276DOI: 10.1002/bies.201500058ISI: 000365259100011PubMedID: 26445215OAI: oai:DiVA.org:uu-280276DiVA: diva2:910415
Available from: 2016-03-09 Created: 2016-03-09 Last updated: 2017-11-30Bibliographically approved

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Mugal, Carina FEllegren, Hans

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