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Suitability Criteria for Adult Related Donors: A Consensus Statement from the Worldwide Network for Blood and Marrow Transplantation Standing Committee on Donor Issues
Med Univ Vienna, Dept Blood Grp Serol & Transfus Med, A-1090 Vienna, Austria..
Swiss Red Cross, Ctr Blood Transfus, Basel, Switzerland.;Univ Basel Hosp, Dept Hematol, CH-4031 Basel, Switzerland..
Med Univ Graz, Div Hematol, Graz, Austria..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
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2015 (English)In: Biology of blood and marrow transplantation, ISSN 1083-8791, E-ISSN 1523-6536, Vol. 21, no 12, 2052-2060 p.Article in journal (Refereed) PublishedText
Abstract [en]

The number of allogeneic hematopoietic stem cell (HSC) transplants performed globally each year continues to increase. Advances in HLA typing, better supportive care, and administration of reduced-intensity conditioning regimens allow treatment of older patients with older sibling donors. Pretransplant donor assessment and testing are very important processes affecting the quality and safety of donation. For unrelated HSC donors detailed recommendations for health assessment have been published, allowing donation only if they are unrestrictedly healthy. Eligibility criteria for related donors are less strict and vary significantly between centers. In situations where a family donor does not meet the suitability criteria for unrelated donors, involved physicians often struggle with the decision whether the matched relative is suitable for donation or not. On behalf of the Worldwide Network for Blood and Marrow Transplantation Standing Committee on Donor Issues, we intended to develop a consensus document with recommendations for donor workup and final clearance of family donors who would not be able to serve as unrelated donors because of their age or pre-existing diseases. This article covers different topics intending to support decision-making, with the goal of minimizing medical risk to the donor and protection of the recipient from transmissible diseases.

Place, publisher, year, edition, pages
2015. Vol. 21, no 12, 2052-2060 p.
Keyword [en]
Related stem cell donor, Suitability criteria
National Category
Immunology in the medical area
URN: urn:nbn:se:uu:diva-270420DOI: 10.1016/j.bbmt.2015.08.009ISI: 000364981700004PubMedID: 26271194OAI: oai:DiVA.org:uu-270420DiVA: diva2:910531
Available from: 2016-03-09 Created: 2015-12-28 Last updated: 2016-03-09Bibliographically approved

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Hagglund, HansBengtsson, Mats
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