114mIn, a candidate for radionuclide therapy: low-energy cyclotron production and labeling of DTPA-D-phe-octreotide
2000 (English)In: Nuclear Medicine and Biology, ISSN 0969-8051, Vol. 27, no 2, 183-188 p.Article in journal (Refereed) Published
A method for production of carrier-free (114m)In (half-life 49.5 days), which is a potential radionuclide for radionuclide therapy of slowly growing tumors, is presented. A target consisting of five enriched cadmium ((114)Cd) foils, each 50 microm thick, was irradiated by protons (from 12.6-6.5 MeV) giving a target yield of 0. 8 MBq/microAh. A simple and cost-efficient thermal diffusion method was used for the separation. The irradiated target foils were heated for 2 h at 306 degrees C and then etched in 0.05 M HCl. The obtained cadmium/indium solution was purified using a cation ion-exchange resin (AG 1 x 8, Bio-Rad Laboratories, Hercules, CA USA). An overall yield of approximately 60% was obtained, whereas the loss of the target material was <1% per separation cycle. The (114m)In production gave (114m)In with high specific radioactivity and was successfully used to label diethylenetriamine pentaacetic acid (DTPA)-D-Phe-octreotide. Furthermore, no difference in biodistribution between [(114m)In]- and [(111)In]-DTPA-D-Phe(1)-octreotide in tumor-bearing nude mice was seen. The high radionuclide uptake in the tumors indicates a good receptor binding of the labeled octreotide.
Place, publisher, year, edition, pages
2000. Vol. 27, no 2, 183-188 p.
114mIn, Production, [114mIn]DTPA-D-Phe1-octreotide, Labeling, Animal study
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-63149DOI: 10.1016/S0969-8051(99)00096-7PubMedID: 10773548OAI: oai:DiVA.org:uu-63149DiVA: diva2:91060