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Post mTBI fatigue is associated with abnormal brain functional connectivity
Karolinska Univ Hosp Huddinge, Dept Diagnost Med Phys, Stockholm, Sweden.;Karolinska Inst, Div Med Imaging & Technol, Dept Clin Sci Intervent & Technol, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Karolinska Inst, KIDS, Danderyd Hosp, Dept Clin Sci, Solnavagen 1, S-17177 Solna, Sweden..
Karolinska Inst, KIDS, Danderyd Hosp, Dept Clin Sci, Solnavagen 1, S-17177 Solna, Sweden.;Stora Skondal Fdn, Neurol Rehabil Clin, Stockholm, Sweden..
Karolinska Inst, KIDS, Danderyd Hosp, Dept Clin Sci, Solnavagen 1, S-17177 Solna, Sweden..
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2016 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, 21183Article in journal (Refereed) Published
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Abstract [en]

This study set out to investigate the behavioral correlates of changes in resting-state functional connectivity before and after performing a 20 minute continuous psychomotor vigilance task (PVT) for patients with chronic post-concussion syndrome. Ten patients in chronic phase after mild traumatic brain injury (mTBI) with persisting symptoms of fatigue and ten matched healthy controls participated in the study. We assessed the participants' fatigue levels and conducted resting-state fMRI before and after a sustained PVT. We evaluated the changes in brain functional connectivity indices in relation to the subject's fatigue behavior using a quantitative data-driven analysis approach. We found that the PVT invoked significant mental fatigue and specific functional connectivity changes in mTBI patients. Furthermore, we found a significant linear correlation between self-reported fatigue and functional connectivity in the thalamus and middle frontal cortex. Our findings indicate that resting-state fMRI measurements may be a useful indicator of performance potential and a marker of fatigue level in the neural attentional system.

Place, publisher, year, edition, pages
2016. Vol. 6, 21183
National Category
Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-280240DOI: 10.1038/srep21183ISI: 000370176300003PubMedID: 26878885OAI: oai:DiVA.org:uu-280240DiVA: diva2:910615
Funder
Swedish Research Council
Note

De 2 första författarna delar förstaförfattarskapet.

Available from: 2016-03-09 Created: 2016-03-09 Last updated: 2017-11-30Bibliographically approved

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