uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Post mTBI fatigue is associated with abnormal brain functional connectivity
Karolinska Univ Hosp Huddinge, Dept Diagnost Med Phys, Stockholm, Sweden.;Karolinska Inst, Div Med Imaging & Technol, Dept Clin Sci Intervent & Technol, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Karolinska Inst, KIDS, Danderyd Hosp, Dept Clin Sci, Solnavagen 1, S-17177 Solna, Sweden..
Karolinska Inst, KIDS, Danderyd Hosp, Dept Clin Sci, Solnavagen 1, S-17177 Solna, Sweden.;Stora Skondal Fdn, Neurol Rehabil Clin, Stockholm, Sweden..
Karolinska Inst, KIDS, Danderyd Hosp, Dept Clin Sci, Solnavagen 1, S-17177 Solna, Sweden..
Show others and affiliations
2016 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, 21183Article in journal (Refereed) PublishedText
Abstract [en]

This study set out to investigate the behavioral correlates of changes in resting-state functional connectivity before and after performing a 20 minute continuous psychomotor vigilance task (PVT) for patients with chronic post-concussion syndrome. Ten patients in chronic phase after mild traumatic brain injury (mTBI) with persisting symptoms of fatigue and ten matched healthy controls participated in the study. We assessed the participants' fatigue levels and conducted resting-state fMRI before and after a sustained PVT. We evaluated the changes in brain functional connectivity indices in relation to the subject's fatigue behavior using a quantitative data-driven analysis approach. We found that the PVT invoked significant mental fatigue and specific functional connectivity changes in mTBI patients. Furthermore, we found a significant linear correlation between self-reported fatigue and functional connectivity in the thalamus and middle frontal cortex. Our findings indicate that resting-state fMRI measurements may be a useful indicator of performance potential and a marker of fatigue level in the neural attentional system.

Place, publisher, year, edition, pages
2016. Vol. 6, 21183
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-280240DOI: 10.1038/srep21183ISI: 000370176300003PubMedID: 26878885OAI: oai:DiVA.org:uu-280240DiVA: diva2:910615
Swedish Research Council

De 2 första författarna delar förstaförfattarskapet.

Available from: 2016-03-09 Created: 2016-03-09 Last updated: 2016-03-09Bibliographically approved

Open Access in DiVA

fulltext(1318 kB)24 downloads
File information
File name FULLTEXT01.pdfFile size 1318 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed
By organisation
Centrum för klinisk forskning i Sörmland (CKFD)
In the same journal
Scientific Reports
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 24 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 32 hits
ReferencesLink to record
Permanent link

Direct link