uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Functional versus chemical diversity: is biodiversity important for drug discovery?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
2002 (English)In: TIPS - Trends in Pharmacological Sciences, ISSN 0165-6147, Vol. 23, no 5, 225-231 p.Article in journal (Refereed) Published
Abstract [en]

Prospecting the full biodiversity of nature to find leads for new drugs is not necessary. Because finding leads is aimed at identifying biological activity, structure is of secondary importance. Furthermore, although natural chemical diversity might be unrivalled, functional diversity is bound to be considerably less. It is likely that many millions of chemically distinct molecules exist in nature but it is inconceivable that the number of different biological functions is near this number. This is corroborated by knowledge obtained from the genome sequences of an increasing number of species. It is unlikely that ligands for specific molecular targets are restricted to one species and even individual compounds are often found in more than one species. Important molecular mechanisms are likely to be ubiquitous and there are no a priori reasons to assume that some are restricted to, for example, tropical rainforests. Thus, there are no obvious advantages of ‘biodiversity prospecting’, which will, possibly, endanger fragile ecosystems in the search for rare species.

Place, publisher, year, edition, pages
2002. Vol. 23, no 5, 225-231 p.
Keyword [en]
functional diversity; biodiversity, ; natural compounds; drug discovery; lead finding; chemical diversity
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-63195DOI: 10.1016/S0165-6147(02)02007-2PubMedID: 12008000OAI: oai:DiVA.org:uu-63195DiVA: diva2:91106
Available from: 2006-09-08 Created: 2006-09-08 Last updated: 2009-10-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Division of Pharmacognosy
In the same journal
TIPS - Trends in Pharmacological Sciences
Pharmaceutical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 190 hits
ReferencesLink to record
Permanent link

Direct link