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Detection of Epstein-Barr virus, but not human herpesvirus 8, DNA in cervical secretions from Swedish women by real-time polymerase chain reaction
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Dermatology and Venereology)
2001 (English)In: Sexually Transmitted Diseases, ISSN 0148-5717, E-ISSN 1537-4521, Vol. 28, no 5, 300-306 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8) are two related herpesviruses that may be sexually transmitted.

GOAL: To examine the presence of HHV-8 and EBV DNA in the female genital tract.

STUDY DESIGN: Real-time polymerase chain reaction systems for quantification of DNA from HHV-8, EBV, and herpes simplex virus type 2 were developed and used for examination of cervical secretions from 112 Swedish women. HHV-8, EBV, and herpes simplex virus type 2 serology was also performed on samples from all subjects.

RESULTS: EBV DNA was found in 10 cervical secretion samples, sometimes in high amounts. No cervical secretion or leukocyte sample contained detectable HHV-8 DNA. Antibodies to HHV-8-latent and -lytic antigens were found in 2.7 % and 24% of serum samples, respectively.

CONCLUSION: This study supports a possible sexual route of transmission for EBV but not for HHV-8. The new real-time polymerase chain reaction systems could be valuable in future studies of relations between virus load and disease

Place, publisher, year, edition, pages
2001. Vol. 28, no 5, 300-306 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-63201PubMedID: 11354271OAI: oai:DiVA.org:uu-63201DiVA: diva2:91112
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-10-15Bibliographically approved

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