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Resonant X-ray emission spectroscopy of platinum(II) anticancer complexes
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry. Polish Acad Sci, Inst Phys Chem, Warsaw, Poland..
Polish Acad Sci, Inst Nucl Sci, PL-31342 Krakow, Poland.;Paul Scherrer Inst, CH-5232 Villigen, Switzerland..
Polish Acad Sci, Inst Nucl Sci, PL-31342 Krakow, Poland..
Paul Scherrer Inst, CH-5232 Villigen, Switzerland..
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2016 (English)In: The Analyst, ISSN 0003-2654, E-ISSN 1364-5528, Vol. 141, no 4, 1226-1232 p.Article in journal (Refereed) Published
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Abstract [en]

Platinum-based drugs are commonly used in cancer treatment. The biological activity of a metallodrug is obviously closely related to its chemical and stereochemical characteristics. An overlooked aspect is the effect of the ligand to the electronic structure of the metal atom (coordinated atom). We report herein a Resonant X-ray Emission Spectroscopy (RXES) study on the chemical speciation of chiral platinum complexes in which diastereomers are distinguished on the basis of their metal electronic configuration. This demonstrates RXES high chemical speciation capabilities, a necessary property to further investigate the reactivity of the Pt atom towards nucleophiles or bionucleophiles, and an important complement the previously reported RXES abilities, namely that it can be employed for in situ studies at physiological concentrations.

Place, publisher, year, edition, pages
2016. Vol. 141, no 4, 1226-1232 p.
National Category
Analytical Chemistry
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URN: urn:nbn:se:uu:diva-280905DOI: 10.1039/c5an02490kISI: 000369617600007PubMedID: 26805912OAI: oai:DiVA.org:uu-280905DiVA: diva2:912316
Funder
EU, FP7, Seventh Framework Programme, 290605
Available from: 2016-03-16 Created: 2016-03-16 Last updated: 2017-11-30Bibliographically approved

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Sa, JacintoFernandes, Daniel L. A.

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