Resonant X-ray emission spectroscopy of platinum(II) anticancer complexes
2016 (English)In: The Analyst, ISSN 0003-2654, E-ISSN 1364-5528, Vol. 141, no 4, 1226-1232 p.Article in journal (Refereed) PublishedText
Platinum-based drugs are commonly used in cancer treatment. The biological activity of a metallodrug is obviously closely related to its chemical and stereochemical characteristics. An overlooked aspect is the effect of the ligand to the electronic structure of the metal atom (coordinated atom). We report herein a Resonant X-ray Emission Spectroscopy (RXES) study on the chemical speciation of chiral platinum complexes in which diastereomers are distinguished on the basis of their metal electronic configuration. This demonstrates RXES high chemical speciation capabilities, a necessary property to further investigate the reactivity of the Pt atom towards nucleophiles or bionucleophiles, and an important complement the previously reported RXES abilities, namely that it can be employed for in situ studies at physiological concentrations.
Place, publisher, year, edition, pages
2016. Vol. 141, no 4, 1226-1232 p.
IdentifiersURN: urn:nbn:se:uu:diva-280905DOI: 10.1039/c5an02490kISI: 000369617600007PubMedID: 26805912OAI: oai:DiVA.org:uu-280905DiVA: diva2:912316
FunderEU, FP7, Seventh Framework Programme, 290605