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The Role of Mast Cells in Bacterial Infection
Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, Uppsala, Sweden..
Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, Uppsala, Sweden..
2016 (English)In: American Journal of Pathology, ISSN 0002-9440, E-ISSN 1525-2191, Vol. 186, no 1, 4-14 p.Article, review/survey (Refereed) Published
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Abstract [en]

Mast cells (MCs) are particularly abundant at host-environment interfaces, such as skin and intestinal mucosa. Because of their Location, it has been hypothesized that MCs can act as sentinel cells that sense microbial attacks and initiate a protective immune response. Several studies have suggested that animals deficient in MCs exhibit a worsened pathology in various experimental models of bacterial infection. However, other studies have indicated that MCs under certain circumstances may have a detrimental impact on bacterial disease, and there are also recent studies indicating that MCs are dispensable for the clearance of bacterial pathogens. Herein, we review the current knowledge of the role of MCs in bacterial infection.

Place, publisher, year, edition, pages
2016. Vol. 186, no 1, 4-14 p.
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Pathobiology
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URN: urn:nbn:se:uu:diva-280808DOI: 10.1016/j.ajpath.2015.06.024ISI: 000367705300002PubMedID: 26477818OAI: oai:DiVA.org:uu-280808DiVA: diva2:912402
Funder
Swedish Research Council FormasSwedish Research CouncilSwedish Cancer SocietySwedish Heart Lung FoundationTorsten Söderbergs stiftelse
Available from: 2016-03-16 Created: 2016-03-15 Last updated: 2017-11-30Bibliographically approved

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Pejler, Gunnar

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