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Surface metal cation doping of maghemite nanoparticles: modulation of MRI relaxivity features and chelator-free Ga-68-radiolabelling for dual MRI-PET imaging
Bar Ilan Univ, Dept Chem, IL-5290002 Ramat Gan, Israel.;Bar Ilan Univ, Inst Nanotechnol & Adv Mat, IL-5290002 Ramat Gan, Israel..
Bencar AB, Uppsala, Sweden..
Fdn Filarete, I-20139 Milan, Italy..
Fdn Filarete, I-20139 Milan, Italy..
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2015 (English)In: MATERIALS RESEARCH EXPRESS, ISSN 2053-1591, Vol. 2, no 9, 095009Article in journal (Refereed) Published
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Abstract [en]

Magnetically responsive maghemite (gamma-Fe2O3) nanoparticles (NPs) are the subject of current interest due to their potential use as contrast agents for in vivo magnetic resonance imaging (MRI). In addition, PET (positron emission tomography) is another non-invasive molecular imaging modality based on nuclear medicine and short-lived positron radionuclides incorporated in various bioprobes. In previous work (Haviv et al 2010 J. Am. Chem. Soc. 132 12519-12521), Massart magnetite (Fe3O4) oxidation using ceric ammonium nitrate (CAN) was explored. The resulting hydrophilic maghemite (gamma-Fe2O3) NPs formed a stable aqueous colloid/ferrofluid that disclosed a low level of NP surface doping by Ce3/4+ atoms/cations. In this work, magnetically responsive gallium(III) or various other lanthanide(III) cation-doped maghemite NPs were prepared in different ways which influenced their r(2)* MRI relaxivities, which were usually strengthened vs those of known FDA approved ferrofluids. In addition, this resulting NP surface chemistry enabled their direct labeling with PET-enabled Ga-68(III) cations (scheme 1) without using any attached chelating organic species/polymer, providing PET-enabled radioactive magnetic NPs towards a novel dual PET/MRI imaging nanoscale agent.

Place, publisher, year, edition, pages
2015. Vol. 2, no 9, 095009
Keyword [en]
functional maghemite NPs, metal cation doping process for NP surface engineering, Ga-68-labelling of NPs, chelator free labeling of NPs, MRI/PET dual nanoparticulate imaging agents
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Other Chemistry Topics
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URN: urn:nbn:se:uu:diva-280966DOI: 10.1088/2053-1591/2/9/095009ISI: 000370057200009OAI: oai:DiVA.org:uu-280966DiVA: diva2:912434
Funder
EU, FP7, Seventh Framework Programme, 263307
Available from: 2016-03-16 Created: 2016-03-16 Last updated: 2016-04-01Bibliographically approved

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Långström, Bengt

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