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Direct evidence of nitric oxide production in the guinea pig organ of Corti
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Ear-Nose-Throat)
2001 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 121, no 3, 342-345 p.Article in journal (Refereed) Published
Abstract [en]

Production of nitric oxide (NO) in the organ of Corti of the guinea pig was investigated using the new fluorescence indicator 4,5-diaminofluorescein diacetate for direct detection of NO. The organ of Corti, lateral wall of the cochlea and isolated outer and inner hair cells were examined to locate NO production sites. The fluorescence intensities were augmented by stimulation with L-arginine or glutamate, and significantly increased after inoculation with lipopolysaccharide. This is the first direct evidence of NO production in the cochlea. NO may play an important role in the physiology of the organ of Corti and may also be involved in hearing disorders.

Place, publisher, year, edition, pages
2001. Vol. 121, no 3, 342-345 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-63372PubMedID: 11425198OAI: oai:DiVA.org:uu-63372DiVA: diva2:91283
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-02-19Bibliographically approved

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