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Brain-derived neurotrophic factor and nitric oxide synthase inhibitor protect the vestibular organ against gentamicin ototoxicity
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Ear-Nose-Throat)
2002 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 122, no 1, 10-15 p.Article in journal (Refereed) Published
Abstract [en]

In order to find a way to develop a new treatment for inner ear disorders, the effects of a nitric oxide synthase (NOS) inhibitor [N-nitro-L-arginine methylester (L-NAME)] and a neurotrophin [brain-derived neurotrophic factor (BDNF)] were investigated. The effect of L-NAME and BDNF on gentamicin-induced vestibular hair cell damage was investigated by using the in vitro LIVE/DEAD system. Both L-NAME and BDNF individually reduced the vestibular hair cell damage caused by gentamicin but the combination of L-NAME and BDNF was more successful in preventing damage. It is therefore suggested that treatment with a combination of an NOS inhibitor and a neurotrophin will help us to treat inner ear disorders.

Place, publisher, year, edition, pages
2002. Vol. 122, no 1, 10-15 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-63375PubMedID: 11876587OAI: oai:DiVA.org:uu-63375DiVA: diva2:91286
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2010-02-19Bibliographically approved

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