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Development of a chiral non-aqueous capillary electrophoretic system using the partial filling technique with UV and mass spectrometric detection
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.ORCID iD: 0000-0002-0156-8242
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
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2003 (English)In: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 986, no 1, 143-152 p.Article in journal (Refereed) Published
Abstract [en]

A chiral non-aqueous CE system with UV and mass spectrometric detection has been developed. The enantioseparation was promoted by diastereomeric complex (ion-pair) formation between the amines (e.g. salbutamol, atenolol) and the chiral selector, (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid [(-)-DIKGA]. Different solvent mixtures were studied, as well as different concentrations of (-)-DIKGA and ammonium acetate in the background electrolyte. A partial filling technique was developed with a selector plug composed of (-)-DIKGA and ammonium acetate in a solvent mixture of methanol and 2-propanol. The separated enantiomers of pronethalol were detected by a Q-TOF MS system equipped with a sheath-flow electrospray ionization interface.

Place, publisher, year, edition, pages
Elsevier, 2003. Vol. 986, no 1, 143-152 p.
Keyword [en]
Non-aqueous capillary electrophoresis; Enantiomer separation; Partial filling technique; Amines; (2)-DIKGA; Pronethalol
National Category
Analytical Chemistry Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-63662DOI: 10.1016/S0021-9673(02)01866-6PubMedID: 12585332OAI: oai:DiVA.org:uu-63662DiVA: diva2:91573
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-30

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Hedeland, YlvaHedeland, MikaelBondesson, UlfPettersson, Curt

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