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Tactile friction of topical formulations
SP Tech Res Inst Sweden, Box 5607, SE-11486 Stockholm, Sweden.;KTH Royal Inst Technol, Surface & Corros Sci, Stockholm, Sweden..
Omega Pharma Nord, Kista, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy. Omega Pharma Nord, Kista, Sweden..
SP Tech Res Inst Sweden, Box 5607, SE-11486 Stockholm, Sweden.;KTH Royal Inst Technol, Surface & Corros Sci, Stockholm, Sweden..
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2016 (English)In: Skin research and technology, ISSN 0909-752X, E-ISSN 1600-0846, Vol. 22, no 1, 46-54 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background: The tactile perception is essential for all types of topical formulations (cosmetic, pharmaceutical, medical device) and the possibility to predict the sensorial response by using instrumental methods instead of sensory testing would save time and cost at an early stage product development. Here, we report on an instrumental evaluation method using tactile friction measurements to estimate perceptual attributes of topical formulations. Methods: Friction was measured between an index finger and an artificial skin substrate after application of formulations using a force sensor. Both model formulations of liquid crystalline phase structures with significantly different tactile properties, as well as commercial pharmaceutical moisturizing creams being more tactile-similar, were investigated. Friction coefficients were calculated as the ratio of the friction force to the applied load. The structures of the model formulations and phase transitions as a result of water evaporation were identified using optical microscopy. Results: The friction device could distinguish friction coefficients between the phase structures, as well as the commercial creams after spreading and absorption into the substrate. In addition, phase transitions resulting in alterations in the feel of the formulations could be detected. A correlation was established between skin hydration and friction coefficient, where hydrated skin gave rise to higher friction. Also a link between skin smoothening and finger friction was established for the commercial moisturizing creams, although further investigations are needed to analyse this and correlations with other sensorial attributes in more detail. Conclusion: The present investigation shows that tactile friction measurements have potential as an alternative or complement in the evaluation of perception of topical formulations.

Place, publisher, year, edition, pages
2016. Vol. 22, no 1, 46-54 p.
Keyword [en]
skin friction, finger/tactile friction, tactile perception, hydration, topical formulations, moisturizers
National Category
Dermatology and Venereal Diseases
URN: urn:nbn:se:uu:diva-281969DOI: 10.1111/srt.12227ISI: 000370302100007PubMedID: 25783057OAI: oai:DiVA.org:uu-281969DiVA: diva2:916215
Available from: 2016-04-01 Created: 2016-04-01 Last updated: 2016-04-01Bibliographically approved

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