uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cell proliferation and cell death are disturbed during prenatal and postnatal brain development after uranium exposure
Inst Radioprotect & Surete Nucl, Serv Radiobiol & Epidemiol, Lab RadioToxicol Expt, BP 17, F-92262 Fontenay Aux Roses, France..
Inst Radioprotect & Surete Nucl, Serv Radiobiol & Epidemiol, Lab RadioToxicol Expt, BP 17, F-92262 Fontenay Aux Roses, France..
Inst Radioprotect & Surete Nucl, Serv Radiobiol & Epidemiol, Lab RadioToxicol Expt, BP 17, F-92262 Fontenay Aux Roses, France..
Inst Radioprotect & Surete Nucl, Serv Radiobiol & Epidemiol, Lab RadioToxicol Expt, BP 17, F-92262 Fontenay Aux Roses, France..
Show others and affiliations
2016 (English)In: Neurotoxicology, ISSN 0161-813X, E-ISSN 1872-9711, Vol. 52, 34-45 p.Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

The developing brain is more susceptible to neurotoxic compounds than adult brain. It is also well known that disturbances during brain development cause neurological disorders in adulthood. The brain is known to be a target organ of uranium (U) exposure and previous studies have noted that internal U contamination of adult rats induces behavioral disorders as well as affects neurochemistry and neurophysiological properties. In this study, we investigated whether depleted uranium (DU) exposure affects neurogenesis during prenatal and postnatal brain development. We examined the structural morphology of the brain, cell death and finally cell proliferation in animals exposed to DU during gestation and lactation compared to control animals. Our results showed that DU decreases cell death in the cortical neuroepithelium of gestational day (GD) 13 embryos exposed at 40 mg/L and 120 mg/L and of GD18 fetuses exposed at 120 mg/L without modification of the number of apoptotic cells. Cell proliferation analysis showed an increase of BrdU labeling in the dentate neuroepithelium of fetuses from GD18 at 120 mg/L. Postnatally, cell death is increased in the dentate gyrus of postnatal day (PND) 0 and PND5 exposed pups at 120 mg/L and is associated with an increase of apoptotic cell number only at PND5. Finally, a decrease in dividing cells is observed in the dentate gyrus of PND21 rats developmentally exposed to 120 mg/L DU, but not at PNDO and PND5. These results show that DU exposure during brain development causes opposite effects on cell proliferation and cell death processes between prenatal and postnatal development mainly at the highest dose. Although these modifications do not have a major impact in brain morphology, they could affect the next steps of neurogenesis and thus might disrupt the fine organization of the neuronal network.

Place, publisher, year, edition, pages
2016. Vol. 52, 34-45 p.
Keyword [en]
Neurogenesis, Heavy metal, Brain development, Telencephalon, Dentate gyrus
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-282040DOI: 10.1016/j.neuro.2015.10.007ISI: 000370767500004PubMedID: 26506049OAI: oai:DiVA.org:uu-282040DiVA: diva2:916336
Available from: 2016-04-01 Created: 2016-04-01 Last updated: 2017-11-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Eriksson, Per

Search in DiVA

By author/editor
Eriksson, Per
By organisation
Environmental toxicology
In the same journal
Neurotoxicology
Pharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 204 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf