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The single breath nitrogen test and mortality: A 38 years follow up
Univ Gothenburg, Sahlgrenska Acad, Dept Resp Med & Allergol, Inst Med, Gothenburg, Sweden..
Univ Gothenburg, Sahlgrenska Acad, Dept Resp Med & Allergol, Inst Med, Gothenburg, Sweden..
Univ Gothenburg, Sahlgrenska Acad, Dept Resp Med & Allergol, Inst Med, Gothenburg, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
2016 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 112, 75-80 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background: Spirometry data predict mortality, but are less sensitive to detect dysfunction in small airways as compared to the slope of phase III (the N-2 slope) of the single breath nitrogen test. The association between the N-2 slope and mortality has been studied with conflicting results. In the present study the prognostic importance of the N-2 slope was tested taking spirometry variables into account. Methods: A systematic general population sample of 595 middle-aged men had a baseline investigation with lung function tests including spirometry and the N-2 slope. Age, smoking, and anthropometry variables were registered. The cohort was followed up regarding survival for 38 years. Results: The sample was subdivided by tertiles of the N-2 slope. A proportional hazards regression analysis was performed for each group of covariates: anthropometric, smoking variables, and spirometry variables, after accounting for age. Covariates with significant impact on mortality and the highest chi-square levels were smoking habit score and forced expired volume in 1 s corrected for height. These variables, in addition to age and the N-2 tertiles were entered into a final proportional hazards regression analysis. In this multivariate model, mortality was significantly related to age (p < .0001), smoking habit score (p < .0001) and the N-2 tertiles (p = .0004), but not to FEV1 when N-2 slope was allowed for in the model. Conclusions: Dysfunction in small airways as measured by the N-2 slope is significantly associated with overall mortality in middle-aged men, and outrivals spirometry as a predictor in multivariate analysis.

Place, publisher, year, edition, pages
2016. Vol. 112, 75-80 p.
Keyword [en]
Mortality, Single breath nitrogen test, Spirometry, Smoking, Small airways function, Epidemiology
National Category
Respiratory Medicine and Allergy Cardiac and Cardiovascular Systems
URN: urn:nbn:se:uu:diva-282310DOI: 10.1016/j.rmed.2016.01.002ISI: 000371096800011PubMedID: 26803380OAI: oai:DiVA.org:uu-282310DiVA: diva2:916860
Available from: 2016-04-05 Created: 2016-04-05 Last updated: 2016-04-05Bibliographically approved

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