uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The single breath nitrogen test and mortality: A 38 years follow up
Univ Gothenburg, Sahlgrenska Acad, Dept Resp Med & Allergol, Inst Med, Gothenburg, Sweden..
Univ Gothenburg, Sahlgrenska Acad, Dept Resp Med & Allergol, Inst Med, Gothenburg, Sweden..
Univ Gothenburg, Sahlgrenska Acad, Dept Resp Med & Allergol, Inst Med, Gothenburg, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
2016 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 112, 75-80 p.Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

Background: Spirometry data predict mortality, but are less sensitive to detect dysfunction in small airways as compared to the slope of phase III (the N-2 slope) of the single breath nitrogen test. The association between the N-2 slope and mortality has been studied with conflicting results. In the present study the prognostic importance of the N-2 slope was tested taking spirometry variables into account. Methods: A systematic general population sample of 595 middle-aged men had a baseline investigation with lung function tests including spirometry and the N-2 slope. Age, smoking, and anthropometry variables were registered. The cohort was followed up regarding survival for 38 years. Results: The sample was subdivided by tertiles of the N-2 slope. A proportional hazards regression analysis was performed for each group of covariates: anthropometric, smoking variables, and spirometry variables, after accounting for age. Covariates with significant impact on mortality and the highest chi-square levels were smoking habit score and forced expired volume in 1 s corrected for height. These variables, in addition to age and the N-2 tertiles were entered into a final proportional hazards regression analysis. In this multivariate model, mortality was significantly related to age (p < .0001), smoking habit score (p < .0001) and the N-2 tertiles (p = .0004), but not to FEV1 when N-2 slope was allowed for in the model. Conclusions: Dysfunction in small airways as measured by the N-2 slope is significantly associated with overall mortality in middle-aged men, and outrivals spirometry as a predictor in multivariate analysis.

Place, publisher, year, edition, pages
2016. Vol. 112, 75-80 p.
Keyword [en]
Mortality, Single breath nitrogen test, Spirometry, Smoking, Small airways function, Epidemiology
National Category
Respiratory Medicine and Allergy Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-282310DOI: 10.1016/j.rmed.2016.01.002ISI: 000371096800011PubMedID: 26803380OAI: oai:DiVA.org:uu-282310DiVA: diva2:916860
Available from: 2016-04-05 Created: 2016-04-05 Last updated: 2017-11-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Svärdsudd, Kurt

Search in DiVA

By author/editor
Svärdsudd, Kurt
By organisation
Family Medicine and Preventive Medicine
In the same journal
Respiratory Medicine
Respiratory Medicine and AllergyCardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 350 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf