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Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Catholic Univ, Dept Lab Med, Rome, Italy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
Catholic Univ, Dept Neurol, Rome, Italy.
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2016 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 292, 21-26 p.Article in journal (Refereed) Published
Abstract [en]

Myasthenia gravis (MG) patients with antibodies against the muscle specific tyrosine kinase (MuSK+) have predominantly involvement of cranio-bulbar muscles and do not display thymus pathology, as do acetylcholine receptor antibody seropositive (AChR+) MG patients. In search of novel biomarkers for MuSK+ MG, we evaluated circulating serum microRNAs. Four analyzed microRNAs were specifically elevated in MuSK+ MG patient serum samples: let-7a-5p, let-7f-5p, miR-151a-3p and miR-423-5p. The circulating microRNA profile in MuSK+ MG differs from the profile previously observed in the serum of AChR+ MG, thus indicating the etiological difference between these two entities. We propose that the identified microRNAs could serve as potential serum biomarkers for MuSK+ MG.

Place, publisher, year, edition, pages
2016. Vol. 292, 21-26 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-282333DOI: 10.1016/j.jneuroim.2016.01.003ISI: 000372561600003PubMedID: 26943954OAI: oai:DiVA.org:uu-282333DiVA: diva2:916872
Funder
Swedish Society of Medicine, SLS-330141Swedish Research Council, VR-523-2014-2048
Available from: 2016-04-05 Created: 2016-04-05 Last updated: 2017-11-30Bibliographically approved

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Punga, TanelLewandowska, MartaPunga, Anna Rostedt

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