Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis.
2016 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 292, 21-26 p.Article in journal (Refereed) Published
Myasthenia gravis (MG) patients with antibodies against the muscle specific tyrosine kinase (MuSK+) have predominantly involvement of cranio-bulbar muscles and do not display thymus pathology, as do acetylcholine receptor antibody seropositive (AChR+) MG patients. In search of novel biomarkers for MuSK+ MG, we evaluated circulating serum microRNAs. Four analyzed microRNAs were specifically elevated in MuSK+ MG patient serum samples: let-7a-5p, let-7f-5p, miR-151a-3p and miR-423-5p. The circulating microRNA profile in MuSK+ MG differs from the profile previously observed in the serum of AChR+ MG, thus indicating the etiological difference between these two entities. We propose that the identified microRNAs could serve as potential serum biomarkers for MuSK+ MG.
Place, publisher, year, edition, pages
2016. Vol. 292, 21-26 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-282333DOI: 10.1016/j.jneuroim.2016.01.003ISI: 000372561600003PubMedID: 26943954OAI: oai:DiVA.org:uu-282333DiVA: diva2:916872
FunderSwedish Society of Medicine, SLS-330141Swedish Research Council, VR-523-2014-2048