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Low vitamin D levels in healthy controls and patients with autoimmune neuromuscular disorders in Greece
Univ Patras, Sch Med, Dept Neurol, GR-26110 Patras, Greece..
Univ Patras, Sch Med, Dept Neurol, GR-26110 Patras, Greece..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
2016 (English)In: Acta Neurologica Belgica, ISSN 0300-9009, E-ISSN 2240-2993, Vol. 116, no 1, 57-63 p.Article in journal (Refereed) Published
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Abstract [en]

Normal autoimmune function is dependent on adequate levels of activated vitamin D, 25 hydroxy vitamin D [25(OH) D]. A recent study presented deficiency of 25(OH) D levels in Swedish MG patients. We aimed to study 25(OH) D levels in patients with MG and autoimmune polyneuropathies (PNP) at a southern latitude in Greece. Plasma levels of 25(OH) D were analyzed in Greek patients with MG (n = 19), immune-mediated PNP (N = 11) and in 30 Greek healthy age-and sex-matched controls. Ten MG patients received supplementation with vitamin D3. The MG Composite Score (MGC) and MG quality of life assessed disease severity in MG patients, whereas the INCAT Disability Scale assessed clinical features in the PNP patients. MG patients with and without vitamin D3 supplementation had higher 25(OH) D levels (mean 58.8 +/- 16.3 and 62.0 +/- 22.4 nmol/L, respectively) than PNP patients (mean 42.1 +/- 11.5 nmol/L, p = 0.01) and healthy controls (mean 45.7 +/- 13.8 nmol/L, p = 0.01). Plasma 25(OH) D levels was lower with age in all groups. There were no correlations between 25(OH) D and disease duration, MGC score, or INCAT score. Vitamin D deficiency was found in all Greek patient groups and healthy controls. Levels of 25(OH) D were higher in MG patients with as well as without vitamin D supplementation compared to healthy controls, whereas CIDP/GBS patients had levels similar to controls.

Place, publisher, year, edition, pages
2016. Vol. 116, no 1, 57-63 p.
Keyword [en]
Myasthenia gravis, Guillain-Barre syndrome, Vitamin D, Autoimmune polyneuropathy
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-282287DOI: 10.1007/s13760-015-0512-2ISI: 000370840700011PubMedID: 26183131OAI: oai:DiVA.org:uu-282287DiVA: diva2:916932
Funder
Lars Hierta Memorial Foundation
Available from: 2016-04-05 Created: 2016-04-05 Last updated: 2017-11-30Bibliographically approved

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Punga, Anna Rostedt

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