uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
HAdV-2-suppressed growth of SV40 T antigen-transformed mouse mammary epithelial cell-induced tumours in SCID mice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Lund Univ, Div Med Microbiol, S-22100 Lund, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Vrije Univ Amsterdam Med Ctr, Dept Med Oncol, Angiogenesis Lab, Amsterdam, Netherlands..
Show others and affiliations
2016 (English)In: Virology, ISSN 0042-6822, E-ISSN 1096-0341, Vol. 489, 44-50 p.Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

Human adenovirus (HAdV) vectors are promising tools for cancer therapy, but the shortage of efficient animal models for productive HAdV infections has restricted the evaluation of systemic effects to mainly immunodeficient mice. Previously, we reported a highly efficient replication of HAdV-2 in a non-tumorigenic mouse mammary epithelial cell line, NMuMG. Here we show that HAdV-2 gene expression and progeny formation in NMuMG cells transformed with the SV40 T antigen (NMuMG-T cells) were as efficient as in the parental NMuMG cells. Injection of HAdV-2 into tumours established by NMuMG-T in SCID mice caused reduced tumour growth and signs of intratumoural lesions. HAdV-2 replicated within the NMuMG-T-established tumours, but not in interspersed host-derived tissues within the tumours. The specific infection of NMuMG-T-derived tumours was verified by the lack of viral DNA in kidney, lung or spleen although low levels of viral DNA was occasionally found in liver.

Place, publisher, year, edition, pages
2016. Vol. 489, 44-50 p.
Keyword [en]
Oncolytic adenovirus, Murine cells, Anti-tumour activity, Permissive infection, Viral replication
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-282389DOI: 10.1016/j.virol.2015.11.031ISI: 000370892100005PubMedID: 26707269OAI: oai:DiVA.org:uu-282389DiVA: diva2:917040
Funder
Swedish Cancer Society
Available from: 2016-04-05 Created: 2016-04-05 Last updated: 2017-11-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Cao, XiaofangYu, DiEssand, MagnusAkusjärvi, GöranJohansson, StaffanSvensson, Catharina

Search in DiVA

By author/editor
Cao, XiaofangYu, DiEssand, MagnusAkusjärvi, GöranJohansson, StaffanSvensson, Catharina
By organisation
Department of Medical Biochemistry and MicrobiologyClinical Immunology
In the same journal
Virology
Infectious Medicine

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 819 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf