Microwave Promoted Transcarbamylation Reaction of Sulfonylcarbamates under Continuous-Flow Conditions
2016 (English)In: Organic Process Research & Development, ISSN 1083-6160, E-ISSN 1520-586X, Vol. 20, no 2, 440-445 p.Article in journal (Refereed) PublishedText
Successful conditions for the transcarbamylation/transesterification reaction of sulfonylcarbamates with alcohols by microwave heating under continuous flow conditions were developed. After optimization of the processes, two series of O-alkylsulfonylcarbamates were obtained in high yields and purities using microwave transparent borosilicate tube reactors. In order to also illustrate the usefulness of the protocol in a medicinal chemistry context, the methodology was used for the synthesis of three angiotensin II type 2 receptor ligands.
Place, publisher, year, edition, pages
2016. Vol. 20, no 2, 440-445 p.
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Pharmaceutical Sciences
IdentifiersURN: urn:nbn:se:uu:diva-282387DOI: 10.1021/acs.oprd.5b00323ISI: 000370767600033OAI: oai:DiVA.org:uu-282387DiVA: diva2:917048
FunderEU, FP7, Seventh Framework Programme, REGPOT-CT-2013-316149-InnovaBalt