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Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.
Institute of Molecular and Cell Biology, Singapore, Singapore.
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2014 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 46, no 1Article in journal (Refereed) Published
Abstract [en]

The most common risk factor for developing hepatocellular carcinoma (HCC) is chronic infection with hepatitis B virus (HBV). To better understand the evolutionary forces driving HCC, we performed a near-saturating transposon mutagenesis screen in a mouse HBV model of HCC. This screen identified 21 candidate early stage drivers and a very large number (2,860) of candidate later stage drivers that were enriched for genes that are mutated, deregulated or functioning in signaling pathways important for human HCC, with a striking 1,199 genes being linked to cellular metabolic processes. Our study provides a comprehensive overview of the genetic landscape of HCC.

Place, publisher, year, edition, pages
2014. Vol. 46, no 1
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-282513DOI: 10.1038/ng.2847PubMedID: 24316982OAI: oai:DiVA.org:uu-282513DiVA: diva2:917153
Available from: 2016-04-05 Created: 2016-04-05 Last updated: 2016-04-07Bibliographically approved

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