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Effects on Weight, Blood Lipids, Serum Fatty Acid Profile and Coagulation by an Energy-Dense Formula to Older Care Residents: A Randomized Controlled Crossover Trial
Huddinge Municipal, Huddinge, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
Karolinska Inst, Clin Geriatr Neurobiol Care Sci & Soc, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Clin Nutr & Dietet, Stockholm, Sweden..
2016 (English)In: Journal of the American Medical Directors Association, ISSN 1525-8610, E-ISSN 1538-9375, Vol. 17, no 3, UNSP 275.e5Article in journal (Refereed) PublishedText
Abstract [en]

Objectives: Dietary intake in frail old adults is often lower than estimated needs. The aim of this study was to evaluate the effects of an energy-dense oral supplement on nutritional status, food intake, and physical function in residents living in care residential homes. Design: Randomized controlled intervention trial with a crossover design. Setting: Five care residential homes in the southern Stockholm area. Participants: Older people living at care residential homes: age 65 or older, malnourished or at risk of malnutrition according to Mini Nutritional Assessment-Short Form (MNA-SF). Intervention: Energy-dense formula (oleic and linoleic acid emulsion enriched with protein and micronutrients) (Calogen Extra, Nutricia) 30 mL distributed 3 times daily for 6 weeks. Measurements: Body weight, 3-day food and fluid record, appetite rating, and physical function (ie, Short Physical Performance Battery, grip strength, and peak expiratory flow). Biochemical indicators of nutritional status, blood lipids, and serum phospholipid fatty acid (FA) profile. Results: Twenty-eight participants completed the 2 phases of the crossover study; group A (n = 14, 87 +/- 6 years, 50% women) and group B (n = 14, 82 +/- 8 years, 71% women). The intervention periods combined resulted in significantly (P <.05) increased energy intake (238 +/- 544 kcal), weight gain (1.4 +/- 3.7 kg), improved appetite, relative reduction of saturated FA and increase in polyunsaturated FA, increased apoliporotein A, and reduced serum fibrinogen (-0.9 +/- 1.5 g/L). Conclusion: Distribution of an oleic and linoleic acid based fat emulsion enriched with protein and micronutrients (Calogen Extra) 3 times daily to old people in care residential homes improved nutritional status, had positive effects on fatty acid profile and blood lipids, and a potential antithrombotic effect.

Place, publisher, year, edition, pages
2016. Vol. 17, no 3, UNSP 275.e5
Keyword [en]
Older people, energy-dense oral supplement, fatty acids, coagulation factors
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URN: urn:nbn:se:uu:diva-282474DOI: 10.1016/j.jamda.2015.12.005ISI: 000370950000019PubMedID: 26810442OAI: oai:DiVA.org:uu-282474DiVA: diva2:917156
Available from: 2016-04-05 Created: 2016-04-05 Last updated: 2016-04-05Bibliographically approved

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