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The effect of crosslinking density on molecularly imprinted polymer morphology and recognition
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC. Linnaeus Univ, Ctr Biomat Chem, Bioorgan & Biophys Chem Lab, SE-39182 Kalmar, Sweden.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC. Linnaeus Univ, Ctr Biomat Chem, Bioorgan & Biophys Chem Lab, SE-39182 Kalmar, Sweden.
2016 (English)In: European Polymer Journal, ISSN 0014-3057, E-ISSN 1873-1945, Vol. 75, 423-430 p.Article in journal (Refereed) Published
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Abstract [en]

In this report, the crosslinking density of bupivacaine molecularly imprinted methacrylic acid (MAA)-ethylene glycol dimethacrylate (EGDMA) copolymers was investigated through replacement of EGDMA by methyl methacrylate (MMA). The effects were examined using a series of full-scale MD simulations of pre-polymerization mixtures, equilibrium rebinding studies on the corresponding synthesized polymers and morphology characterization through nitrogen sorption measurements. While the extent of hydrogen bonding between the functional monomer MAA and bupivacaine observed in the MD pre-polymerization mixtures was comparable in each of the systems studied, the decrease in degree of crosslinking impacted directly on polymer morphology as observed in BET and BJH studies of surface area and porosity. Further, decreases in the crosslinking density induced reductions in template rebinding capacity as seen from a series of radio-ligand binding studies, demonstrating the importance of crosslinking on the performance of molecularly imprinted MAA-EGDMA copolymers, the polymer system most commonly used in molecular imprinting science and technology.

Place, publisher, year, edition, pages
2016. Vol. 75, 423-430 p.
Keyword [en]
Molecularly imprinted polymer, Molecular dynamics, Molecular recognition, Molecular imprinting, Morphology, Crosslinking
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-281840DOI: 10.1016/j.eurpolymj.2016.01.008ISI: 000370309400036OAI: oai:DiVA.org:uu-281840DiVA: diva2:917327
Funder
Swedish Research Council, 2014-4573EU, FP7, Seventh Framework Programme, 602699
Available from: 2016-04-06 Created: 2016-03-30 Last updated: 2017-11-30Bibliographically approved

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Golker, KerstinNicholls, Ian A.

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