uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Lipid-lowering treatment patterns in patients with new cardiovascular events - estimates from population-based register data in Sweden
Quantify Res, Hantverkargatan 8, S-11221 Stockholm, Sweden..
Quantify Res, Hantverkargatan 8, S-11221 Stockholm, Sweden..
Strateg Healthcare Solut LLC, Baltimore, MD USA..
Quantify Res, Hantverkargatan 8, S-11221 Stockholm, Sweden.;Karolinska Inst, LIME Med Management Ctr, Stockholm, Sweden..
Show others and affiliations
2016 (English)In: International journal of clinical practice (Esher), ISSN 1368-5031, E-ISSN 1742-1241, Vol. 70, no 3, 222-228 p.Article in journal (Refereed) PublishedText
Abstract [en]

ObjectivesThe aim of this study was to assess treatment patterns of lipid-lowering therapy (LLT) in patients with hyperlipidaemia or prior cardiovascular (CV) events who experience new CV events. MethodsA retrospective population-based cohort study was conducted using Swedish medical records and registers. Patients were included in the study based on a prescription of LLT or CV event history and followed up for up to 7 years for identification of new CV events and assessment of LLT treatment patterns. Patients were stratified into three cohorts based on CV risk level. All outcomes were assessed during the year following index (the date of first new CV event). Adherence was defined as medication possession ratio (MPR) > 0.80. Persistence was defined as no gaps > 60 days in supply of drug used at index. ResultsOf patients with major cardiovascular disease (CVD) history (n = 6881), 49% were not on LLT at index. Corresponding data for CV risk equivalent and low/unknown CV risk patients were 37% (n = 3226) and 38% (n = 2497) respectively. MPR for patients on LLT at index was similar across cohorts (0.74-0.75). The proportions of adherent (60-63%) and persistent patients (56-57%) were also similar across cohorts. Dose escalation from dose at index was seen within all cohorts and 2-3% of patients switched to a different LLT after index while 5-6% of patients augmented treatment by adding another LLT. ConclusionsAlmost 50% of patients with major CVD history were not on any LLT, indicating a potential therapeutic gap. Medication adherence and persistence among patients on LLT were suboptimal.

Place, publisher, year, edition, pages
2016. Vol. 70, no 3, 222-228 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-282830DOI: 10.1111/ijcp.12769ISI: 000371480900007PubMedID: 26799539OAI: oai:DiVA.org:uu-282830DiVA: diva2:917554
Available from: 2016-04-07 Created: 2016-04-07 Last updated: 2016-04-07Bibliographically approved

Open Access in DiVA

fulltext(363 kB)50 downloads
File information
File name FULLTEXT01.pdfFile size 363 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Johansson, Gunnar
By organisation
Family Medicine and Preventive Medicine
In the same journal
International journal of clinical practice (Esher)
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 50 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 129 hits
ReferencesLink to record
Permanent link

Direct link