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Direct and indirect genetic effects of sex-specific mitonuclear epistasis on reproductive ageing
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
Ecole Normale Super Lyon, Dept Biol, Master BioSci, F-69364 Lyon, France..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology. Aarhus Univ, Arhus Inst Adv Studies, Aarhus, Denmark..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
2016 (English)In: Heredity, ISSN 0018-067X, E-ISSN 1365-2540, Vol. 116, no 3, 338-347 p.Article in journal (Refereed) Published
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Abstract [en]

Mitochondria are involved in ageing and their function requires coordinated action of both mitochondrial and nuclear genes. Epistasis between the two genomes can influence lifespan but whether this also holds for reproductive senescence is unclear. Maternal inheritance of mitochondria predicts sex differences in the efficacy of selection on mitonuclear genotypes that should result in differences between females and males in mitochondrial genetic effects. Mitonuclear genotype of a focal individual may also indirectly affect trait expression in the mating partner. We tested these predictions in the seed beetle Callosobruchus maculatus, using introgression lines harbouring distinct mitonuclear genotypes. Our results reveal both direct and indirect sexspecific effects of mitonuclear epistasis on reproductive ageing. Females harbouring coadapted mitonuclear genotypes showed higher lifetime fecundity due to slower senescence relative to novel mitonuclear combinations. We found no evidence for mitonuclear coadaptation in males. Mitonuclear epistasis not only affected age-specific ejaculate weight, but also influenced male age-dependent indirect effects on traits expressed by their female partners (fecundity, egg size, longevity). These results demonstrate important consequences of sex-specific mitonuclear epistasis for both mating partners, consistent with a role for mitonuclear genetic constraints upon sex-specific adaptive evolution.

Place, publisher, year, edition, pages
2016. Vol. 116, no 3, 338-347 p.
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Genetics
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URN: urn:nbn:se:uu:diva-282827DOI: 10.1038/hdy.2015.112ISI: 000371736700010PubMedID: 26732015OAI: oai:DiVA.org:uu-282827DiVA: diva2:917561
Funder
EU, European Research Council, AdG-294333Swedish Research Council, 621-2010-5266
Available from: 2016-04-07 Created: 2016-04-07 Last updated: 2017-11-30Bibliographically approved

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Immonen, ElinaArnqvist, Göran

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