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Axenic mice model.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala universitet - Institutionen för medicinsk cellbiologi.ORCID iD: 0000-0002-8559-5781
2008 (English)In: Innate Immunity / [ed] Jonathan Ewbank, Eric Vivier, Humana Press, 2008, 321-336 p.Chapter in book (Other academic)
Abstract [en]

The interaction of an organism with surrounding microbial communities has a profound impact on its anatomy, physiology, and behavior. The innate immune system plays a major role in the crosstalk between bacteria and the hosts they colonize. Axenic mice provide a powerful in vivo controlled model to decipher the particular interactions between the host and one defined strain, or group of strains, isolated from the "noise" of the rest of the flora. This chapter briefly reviews the specificities of axenic mice and describes the main guidelines to derive, house, and work with axenic mice.

Place, publisher, year, edition, pages
Humana Press, 2008. 321-336 p.
, Methods in Molecular Biology, ISSN 1064-3745 ; 415
Keyword [en]
Axenic mice isolator intestinal flora gnotoxenic germ free
National Category
URN: urn:nbn:se:uu:diva-282875DOI: 10.1007/978-1-59745-570-1_19PubMedID: 18370163ISBN: 978-1-58829-746-4ISBN: 978-1-59745-570-1OAI: oai:DiVA.org:uu-282875DiVA: diva2:917713
Available from: 2016-04-07 Created: 2016-04-07 Last updated: 2016-04-07

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Giraud, Antoine
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