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Fast DNA sequencing via transverse differential conductance
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
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2010 (English)Conference paper, Published paper (Refereed)
Resource type
Text
Abstract [en]

We propose using characteristic transverse differential conductance for solid-state nanopore-based DNA sequencing and have explored this idea by performing molecular dynamics simulations on the translocation progress of single-stranded DNA molecule through the nanopore, and calculating the associated transverse differential conductance. Our results show that measurement of the transverse differential conductance is suitable to successfully discriminate between the four nucleotide types, and we show that this identification could even withstand electrical noise caused by fluctuations due to changes in the DNA orientation. Our findings demonstrate several compelling advantages of the differential conductance approach, which may lead to important applications in rapid genome sequencing.

Place, publisher, year, edition, pages
2010. 313-316 p.
Keyword [en]
Differential conductances; DNA Sequencing; Electrical noise; Genome sequencing; Molecular dynamics simulations; Single-stranded DNA molecules; Solid-state nanopore
National Category
Condensed Matter Physics
Identifiers
URN: urn:nbn:se:uu:diva-283324DOI: 10.1109/SISPAD.2010.5604495Scopus ID: 2-s2.0-78649568967OAI: oai:DiVA.org:uu-283324DiVA: diva2:918953
Conference
15th International Conference on Simulation of Semiconductor Processes and Devices, SISPAD 2010; Bologna; Italy
Projects
KoF U3MEC
Available from: 2016-04-12 Created: 2016-04-12 Last updated: 2016-04-12

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Scheicher, RalphGrigoriev, AntonAhuja, Rajeev

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