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Bioactive spheres: the way of treating dentin hypersensitivity
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medcine)ORCID iD: 0000-0002-7356-3002
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
2016 (English)In: ACS biomaterials science and engineering, ISSN 2373-9878, Vol. 2, no 5, 734-740 p.Article in journal (Refereed) Published
Abstract [en]

Sealing exposed dental tubules is the most effective and long-term way to relieve the pain induced by dental sensitivity. A bioactive hollow sphere (strontium substituted calcium phosphate) was synthesized and added in toothpaste to study its effect on dental hypersensitivity via tooth tubules occlusion and mineralization. The size of spheres is perfect for penetrating into dental tubules, reaching to 20 pm into the tubules. The exposed dental tubules were occluded by spheres and new apatite layer after 3 days brushing. The spheres attached to the surface of dentin and the mineralized surface contained two layers, a porous layer followed by a dense apatite layer. The porous layer can be dissolved in an acidic solution, but the following dense layer could be kept even after soaking in an acid solution. In conclusion, Sr-substituted calcium phosphate spheres could be a good candidate for at-home treatment of dental hypersensitivity.

Place, publisher, year, edition, pages
2016. Vol. 2, no 5, 734-740 p.
Keyword [en]
calcium phosphate, spheres, occlusion, mineralization, dental sensitivity
National Category
Medical Materials
Identifiers
URN: urn:nbn:se:uu:diva-284233DOI: 10.1021/acsbiomaterials.5b00499ISI: 000375893600004OAI: oai:DiVA.org:uu-284233DiVA: diva2:920045
Funder
Swedish Research Council, 2013-5419
Available from: 2016-04-15 Created: 2016-04-15 Last updated: 2017-01-19Bibliographically approved
In thesis
1. Submicron Calcium Phosphate Spheres for Biomedical Applications: Synthesis and Use
Open this publication in new window or tab >>Submicron Calcium Phosphate Spheres for Biomedical Applications: Synthesis and Use
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Calcium phosphate spheres as biomaterials have been attracting attention in recent years. Calcium phosphate occurs naturally in bone, and a hollow structure could be advantageous for drug loading and release. The combination of a calcium phosphate chemistry and a spherical-hollow structure could be an optimal strategy for specific biomaterial applications, e.g., certain dental and drug-delivery applications.

The focus of this thesis is on the synthesis, formation mechanism and applications of hollow, spherical calcium phosphate particles. First, the thesis describes two methods for the synthesis of calcium phosphate (CaP) spherical particles. The first method involves synthesis of hollow calcium phosphate spherical particles via a supersaturated buffer solution based on a previous study. It was utilised to prepare spheres for applications in drug delivery and dentistry. The second method was developed to explain the mechanism of formation of hollow calcium phosphate spheres. It aimed at revealing the particular function of magnesium in the formation of spherical particles. With the use of this modified method, it could be concluded that the only ions active in the formation of CaP spherical particles are calcium ions, phosphate ions and magnesium ions. Compared with the thermodynamics of micellisation, a new model, called three ions virtual micelle effect, was developed to explain the mechanism of the Mg function. Following this mechanism, a series of spherical particles of other compositions were explored. These spherical particles included strontium phosphate, barium phosphate, calcium fluoride, strontium fluoride and barium fluoride.

In this thesis, CaP spheres were studied for the controlled delivery of active ingredients and as active agent for tooth remineralisation. The first investigated application was to control the release of vancomycin from Poly(methyl methacrylate) (PMMA) cement via strontium-doped CaP spheres (SCPS). The results showed that incorporation of CaP spheres into PMMA could enhance antibiotic release while maintaining the mechanical strength. The second application was to control hydrogen peroxide (HP) release from two bleaching gel, in which CP-loaded CaP spheres were the active ingredient. One gel with low HP concentration was developed as an at-home bleaching gel, and one with high HP concentration was developed as an in-office bleaching gel. The results showed that CaP spheres would give a controlled release of peroxide and thus have a potential to increase the efficacy of the bleaching. The third application was to investigate the potential for an anti-sensitivity effect of the spheres, as active agents in toothpaste. We studied the tooth tubules occlusion and the remineralisation effect of CaP spheres. After 7 days of application, the open dentin tubules and surface were fully covered by a newly formed apatite layer, demonstrating the remineralisation potential of the spheres.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2016. 67 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1446
Keyword
calcium phosphate, spheres, dentinal hypersensitivity, drug release, tooth bleaching
National Category
Materials Engineering
Identifiers
urn:nbn:se:uu:diva-305820 (URN)978-91-554-9737-8 (ISBN)
Public defence
2016-12-14, Å4001, Lägerhyddsvägen 1, Uppsala, 13:00 (English)
Opponent
Supervisors
Available from: 2016-11-22 Created: 2016-10-21 Last updated: 2016-11-28

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Xia, WeiQin, TaoEngqvist, Håkan

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