Distinct temporal changes in host cell lncRNA expression during the course of an adenovirus infection
2016 (English)In: Virology, ISSN 0042-6822, E-ISSN 1096-0341, Vol. 492, 242-250 p.Article in journal (Refereed) Published
The deregulation of cellular long non-coding RNA (lncRNA) expression during a human adenovirus infection was studied by deep sequencing. Expression of lncRNAs increased substantially following the progression of the infection. Among 645 significantly expressed lncRNAs, the expression of 398 was changed more than 2-fold. More than 80% of them were up-regulated and 80% of them were detected during the late phase. Eased on the genomic locations of the deregulated lncRNAs in relation to known mRNAs and miRNAs, they were predicted to be involved in growth, structure, apoptosis and wound healing in the early phase, cell proliferation in the intermediate phase and protein synthesis, modification and transport in the late phase. The most significant functions of cellular RNA-binding proteins, previously shown to interact with the deregulated lncRNAs identified here, are involved in RNA splicing, nuclear export and translation events. We hypothesize that adenoviruses exploit the lncRNA network to optimize their reproduction.
Place, publisher, year, edition, pages
2016. Vol. 492, 242-250 p.
Long non-coding RNA (lncRNA); Antisense RNAs; Cellular gene expression; Adenovirus infection; RNA sequencing; RNA-binding proteins (RBPs); lncRNA expression profile
IdentifiersURN: urn:nbn:se:uu:diva-284507DOI: 10.1016/j.virol.2016.02.017ISI: 000374209900027PubMedID: 27003248OAI: oai:DiVA.org:uu-284507DiVA: diva2:920485
FunderMagnus Bergvall FoundationÅke Wiberg Foundation