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Ventilation/perfusion distributions revisited
Oscillogy LLC, Folsom, PA USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
2016 (English)In: Current Opinion in Anaesthesiology, ISSN 0952-7907, E-ISSN 1473-6500, Vol. 29, no 1, 2-7 p.Article, review/survey (Refereed) Published
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Abstract [en]

Purpose of reviewA major cause of hypoxemia in anesthesia is ventilation-perfusion (V-A/Q) mismatch. With more advanced surgery and an aging population, monitoring of V-A/Q is of increasing importance.Recent findingsThe classic multiple inert gas elimination technique has been simplified with a new approach based on mass spectrometry. V-A/Q distributions can also be measured, at the bedside, by varying inspired oxygen concentration. MRI, 3-dimensional single photon emission computed tomography, positron emission tomography, and electrical impedance tomography enable imaging of perfusion and ventilation, and in some of the techniques also the distribution of inflammation. One-lung ventilation with thoracoscopy and capnothorax require careful monitoring of V-A/Q, made possible bedside by electrical impedance tomography. Carbon dioxide, but not air, for pneumoperitoneum enhances shift of perfusion to ventilated regions. Ventilatory support during cardiopulmonary resuscitation causes less V-A/Q mismatch when inspired oxygen concentrations are lower. Mechanisms of redistribution of lung blood flow by inhaled nitric oxide include endothelin-mediated vasoconstriction in collapsed lung regions.SummaryMethods are continuously developing to simplify measurement of V-A/Q and also to relate V-A/Q to inflammation. The recording of V-A/Q has helped to explain important aspects of gas exchange in thoracic anesthesiology and in intensive care medicine.

Place, publisher, year, edition, pages
2016. Vol. 29, no 1, 2-7 p.
Keyword [en]
arterial oxygenation, one-lung ventilation, shunt, V, Q mismatch, ventilation, perfusion ratio
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:uu:diva-282734DOI: 10.1097/ACO.0000000000000269ISI: 000369423600001PubMedID: 26545142OAI: oai:DiVA.org:uu-282734DiVA: diva2:920515
Available from: 2016-04-18 Created: 2016-04-06 Last updated: 2017-11-30Bibliographically approved

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Hedenstierna, Göran

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