uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Soluble factors released by virus specific activated cytotoxicT-lymphocytes induce apoptotic death of astroglioma cell lines
Show others and affiliations
2003 (English)In: Brain Pathology, ISSN 1015-6305, Vol. 13, no 2, 165-175 p.Article in journal (Refereed) Published
Abstract [en]

Astrocytomas and astrogliomas represent the most common types of primary tumors in human central nervous system and are associated with high mortality due to the absence of efficient therapy. Here we demonstrate that, upon antigen-specific activation, cytotoxic T-lymphocytes (CTLs) secrete products that inhibit proliferation and induce apoptosis in a significant proportion of astroglioma cell lines. This effect is tumor specific in that normal cultured astrocytes do not develop apoptotic changes upon exposure to supernatant of activated CTLs. Experiments with purified lymphokines and lymphokine specific blocking antibodies indicate that synergistic activities of tumor necrosis factor (TNF)-alpha and interferon (INF)-gamma are required for the apoptosis inducing effect on some astroglioma cell lines. However, this effect appears to be dependent on additional factors produced by activated CTLs. Our results suggest that local application of factors released by activated CTLs or induction of CTL migration and activation in the tumor site may have a therapeutic effect in patients with astrogliomas.

Place, publisher, year, edition, pages
2003. Vol. 13, no 2, 165-175 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-64199DOI: 10.1111/j.1750-3639.2003.tb00016.xPubMedID: 12744470OAI: oai:DiVA.org:uu-64199DiVA: diva2:92110
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2009-07-27Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Westermark, Bengt
By organisation
Department of Genetics and Pathology
In the same journal
Brain Pathology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 276 hits
ReferencesLink to record
Permanent link

Direct link