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Patient-reported outcomes and visual acuity in patients after 12 months of anti-VEGF-treatment for sight-threatening diabetic macular edema
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
(English)Manuscript (preprint) (Other academic)
Abstract [en]

Aims: To examine objective visual acuity measured with ETDRS, retinal thickness (OCT), and patient reported outcome measurements in patients treated with anti-VEGF treatment for visual impairment due to DME in routine clinical care after 12 months.

Methods: In this cross-sectional study, 58 patients (29 females and 29 males; mean age, 68 years) with type 1 and type 2 diabetes diagnosed with macular edema were included. Medical data and two questionnaires were collected; an eye-specific (NEI VFQ-25) and a generic health-related quality of life questionnaire (SF-36) were used after anti-VEGF treatment.

Results: Thirty patients had significantly improved visual acuity (p-value ˂ 0.001), and 27 patients had no improved visual acuity at 12 months. Both groups had significantly (p-value ˂ 0.001), reduced retinal thickness (OCT). The patients with improved visual acuity had significantly improved scores for NEI VFQ-25 subscales including general health (p-value ˂ 0.004),, general vision (p-value - 0.001), near activities (p-value- 0.015), distance activities (p-value- 0.008), and composite score (p-value 0.024), but no significant changes in scores were found in the group without improvements in visual acuity.

Conclusions: The patient-reported outcome measurements improved in the total patient population. A high HbA1c at baseline may be a risk factor for poor treatment effects.

Keyword [en]
patient-reported measurements, diabetic macular edema, anti-VEGF treatment, visual function
National Category
Endocrinology and Diabetes
Research subject
Medical Science
Identifiers
URN: urn:nbn:se:uu:diva-285842OAI: oai:DiVA.org:uu-285842DiVA: diva2:921213
Available from: 2016-04-19 Created: 2016-04-19 Last updated: 2016-04-19

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CiteExportLink to record
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Citation style
  • apa
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More styles
Language
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  • en-US
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  • nn-NB
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  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
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