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Experimental intracerebral and subarachnoid/intraventricular haemorrhages
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. (RAD)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. (RAD)
2002 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 43, no 5, 464-73 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To compare the detectability of small experimental intracranial haemorrhages on MR imaging at 0.5 T and 1.5 T, from hyperacute to subacute stages. MATERIAL AND METHODS: 1 ml of autologous blood was injected into the brain of 15 rabbits to create intraparenchymal haematomas. Since the blood partially escaped into the cerebrospinal fluid (CSF) spaces, detectability of subarachnoid and intraventricular blood was also evaluated. MR imaging at 0.5 T and at 1.5 T was repeated up to 14 days, including T1-, proton density- and T2-weighted (w) spin-echo (SE), FLAIR and T2*-w gradient echo (GE) pulse sequences. The last MR investigation was compared to the formalin-fixed brain sections in 7 animals. RESULTS: The intraparenchymal haematomas were best revealed with T2*-w GE sequences, with 100% of sensitivity at 1.5 T and 90-95% at 0.5 T. Blood in the CSF spaces was significantly (p < 0.05) better detected at 1.5 T with T2*-w GE sequences and detected best during the first 2 days. The next most sensitive sequence for intracranial blood was FLAIR. SE sequences were rather insensitive. CONCLUSION: 1.5 T equipment is superior to 0.5 T in the detection of intracranial haemorrhages from acute to subacute stages. T2*-w GE sequences account for this result but other sequences are also needed for a complete examination.

Place, publisher, year, edition, pages
2002. Vol. 43, no 5, 464-73 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-64216PubMedID: 12423456OAI: oai:DiVA.org:uu-64216DiVA: diva2:92127
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-30Bibliographically approved

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