uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Adult honeybees (Apis mellifera L.) abandon hemocytic, but not phenoloxidase-based immunity.
(Webster)ORCID iD: 0000-0003-0772-3431
Show others and affiliations
2008 (English)In: Journal of insect physiology, ISSN 0022-1910, E-ISSN 1879-1611, Vol. 54, no 2Article in journal (Refereed) Published
Abstract [en]

Hemocytes and the (prophenol-) phenoloxidase system constitute the immediate innate immune system in insects. These components of insect immunity are present at any post-embryonic life stage without previous infection. Differences between individuals and species in these immune parameters can reflect differences in infection risk, life expectancy, and biological function. In honeybees which show an age-related division of labor within the worker caste, previous studies demonstrated that foragers show a strongly reduced number of hemoctyes compared to the younger nurse bees. This loss of immune competence has been regarded advantageous with respect to an already high mortality rate due to foraging and to redistribution of energy costs at the colony level. Based on the idea that abandoning hemocytes in all adults would be a reasonably direct regulatory mechanism, we posed the hypothesis that abandoning hemocytic immunity is not restricted to worker honeybees. We tested our hypotheses by performing a comprehensive analysis of hemocyte number and phenoloxidase (PO)-activity levels in immunologically naive workers, queens, and drones. We found that in all three adult phenotypes hemocyte number is dramatically reduced in early adult life. In contrast, we found that the dynamics of PO-activity levels have sex and caste-specific characteristics. In workers, PO activity reached a plateau within the first week of adult life, and in queens enzyme levels continuously increased with age and reached levels twice as high as those found in workers. PO-activity levels slightly declined with age in drones. These data support our hypothesis, from which we infer that the previously reported reduction of hemocyte in foragers is not worker specific but represents a general phenomenon occurring in all honeybee adult phenotypes.

Place, publisher, year, edition, pages
2008. Vol. 54, no 2
National Category
Immunology Zoology
URN: urn:nbn:se:uu:diva-286595DOI: 10.1016/j.jinsphys.2007.11.002PubMedID: 18164310OAI: oai:DiVA.org:uu-286595DiVA: diva2:921779
Available from: 2016-04-21 Created: 2016-04-21 Last updated: 2016-04-21

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Schmid, Martin R
In the same journal
Journal of insect physiology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 7 hits
ReferencesLink to record
Permanent link

Direct link