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Vascular Growth Factors and Glomerular Disease
Northwestern Univ, Feinberg Cardiovasc Res Inst, Chicago, IL 60611 USA.;Northwestern Univ, Div Nephrol & Hypertens, Chicago, IL 60611 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
Northwestern Univ, Feinberg Cardiovasc Res Inst, Chicago, IL 60611 USA.;Northwestern Univ, Div Nephrol & Hypertens, Chicago, IL 60611 USA..
2016 (English)In: ANNUAL REVIEW OF PHYSIOLOGY, VOL 78, ANNUAL REVIEWS, 2016, 437-461 p.Chapter in book (Refereed)
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Text
Abstract [en]

The glomerulus is a highly specialized microvascular bed that filters blood to form primary urinary filtrate. It contains four cell types: fenestrated endothelial cells, specialized vascular support cells termed podocytes, perivascular mesangial cells, and parietal epithelial cells. Glomerular cell-cell communication is critical for the development and maintenance of the glomerular filtration barrier. VEGF, ANGPT, EGF, SEMA3A, TGF-beta, and CXCL12 signal in paracrine fashions between the podocytes, endothelium, and mesangium associated with the glomerular capillary bed to maintain filtration barrier function. In this review, we summarize the current understanding of these signaling pathways in the development and maintenance of the glomerulus and the progression of disease.

Place, publisher, year, edition, pages
ANNUAL REVIEWS, 2016. 437-461 p.
Series
Annual Review of Physiology, ISSN 0066-4278 ; 78
Keyword [en]
VEGF, angiopoietin, podocyte, endothelial cell
National Category
Physiology
Identifiers
URN: urn:nbn:se:uu:diva-285938DOI: 10.1146/annurev-physiol-021115-105412ISI: 000370847600020PubMedID: 26863327ISBN: 978-0-8243-0378-5 (print)OAI: oai:DiVA.org:uu-285938DiVA: diva2:921827
Available from: 2016-04-21 Created: 2016-04-20 Last updated: 2016-04-21Bibliographically approved

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Jeansson, Marie

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