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Novel chemoselective (18)F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions
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2016 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 52, no 36, p. 6083-6086Article in journal (Refereed) Published
Abstract [en]

We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective (18)F-labeling of thiol-containing (bio)molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development.

Place, publisher, year, edition, pages
2016. Vol. 52, no 36, p. 6083-6086
National Category
Radiology, Nuclear Medicine and Medical Imaging
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URN: urn:nbn:se:uu:diva-286827DOI: 10.1039/c6cc01982jISI: 000375346500008PubMedID: 27043419OAI: oai:DiVA.org:uu-286827DiVA, id: diva2:922059
Available from: 2016-04-21 Created: 2016-04-21 Last updated: 2017-11-30Bibliographically approved

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Tolmachev, Vladimir

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Department of Immunology, Genetics and Pathology
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