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Flow control in our vessels: vascular valves make sure there is no way back.
2013 (English)In: Cellular and Molecular Life Sciences (CMLS), ISSN 1420-682X, E-ISSN 1420-9071, Vol. 70, no 6Article in journal (Refereed) Published
Abstract [en]

The efficient transport of blood and lymph relies on competent intraluminal valves that ensure unidirectional fluid flow through the vessels. In the lymphatic vessels, lack of luminal valves causes reflux of lymph and can lead to lymphedema, while dysfunction of venous valves is associated with venous hypertension, varicose veins, and thrombosis that can lead to edema and ulcerations. Despite their clinical importance, the mechanisms that regulate valve formation are poorly understood and have only recently begun to be characterized. Here, we discuss new findings regarding the development of venous and lymphatic valves that indicate the involvement of common molecular mechanisms in regulating valve formation in different vascular beds.

Place, publisher, year, edition, pages
2013. Vol. 70, no 6
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-287139DOI: 10.1007/s00018-012-1110-6PubMedID: 22922986OAI: oai:DiVA.org:uu-287139DiVA: diva2:922249
Available from: 2016-04-22 Created: 2016-04-22 Last updated: 2016-04-22

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